Prehospital Diagnosis and Oxygen Treatment in ST Elevation Myocardial Infarction

Research output: ThesisDoctoral Thesis (compilation)

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Abstract

Introduction
Paper I: An Artificial Neural Network (ANN) was constructed to identify ST Elevation Myocardial Infarction (STEMI) and predict the need for Percutaneous Coronary Intervention (PCI).
Paper II, III and IV: Studies suggest that O2 therapy may be harmful in STEMI patients. We therefore conducted the SOCCER study to evaluate the effects of O2 therapy in STEMI patients.

Methods
Paper I: 560 ambulance ECGs sent to the Cardiac Care Unit (CCU), was together with the CCU physicians interpretation and decision of conducting an acute PCI or not collected, and compared with the interpretation and PCI decision of the ANN.
Paper II, III, IV: Normoxic (≥94%) STEMI patients accepted for acute PCI were in the ambulance randomized to standard care with 10 L/min O2 or room air. A subset of the patients underwent echocardiography for determination of the Left Ventricular Ejection Fraction (LVEF) and the Wall Motion Score Index (WMSI). All patients had a Cardiac Magnetic Resonance Imaging (CMRI) to evaluate Myocardial area at Risk (MaR), Infarct Size (IS) and Myocardial Salvage Index (MSI).

Results
Paper I: The area under the ANN’s receiver operating characteristics curve for STEMI detection as well as predicting the need of acute PCI were very good.
Paper II, III, IV: No significant differences could be shown in discussing MaR, MSI or IS between the O2 group (n=46) and the air group (n=49). Neither could any differences be shown for LVEF and WMSI at the index visit as well after six months between the O2 group (n=46) and the air group (n=41)

Conclusions
Paper I: The results indicate that the number of ECGs sent to the CCU could be reduced with 2/3 as the ANN would safely identify ECGs not being STEMI.
Paper II, III, IV: The results suggest that it is safe to withhold O2 therapy in normoxic, stable STEMI patients.
Original languageEnglish
QualificationDoctor
Awarding Institution
  • Faculty of Medicine
Supervisors/Advisors
  • Ekelund, Ulf, Supervisor
  • Carlsson, Marcus, Supervisor
  • Lundager Forberg, Jakob, Supervisor
Award date2017 Nov 3
Place of PublicationLund
Publisher
Print ISBNs978-91-7619-519-2
DOIs
Publication statusPublished - 2017

Bibliographical note

Defence details
Date: 2017-11-03
Time: 13:00
Place: Belfragesalen, BMC D15, Klinikgatan 32, Lund
External reviewer(s)
Name: [Frischknecht Christensen, Erika
Title: professor
Affiliation: Aalborg University, Denmark
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ISSN: 1652-8220
Lund University, Faculty of Medicine Doctoral Dissertation Series 2017:136

Subject classification (UKÄ)

  • Physiology
  • Other Basic Medicine
  • Anesthesiology and Intensive Care
  • Cardiac and Cardiovascular Systems
  • Radiology, Nuclear Medicine and Medical Imaging
  • Other Clinical Medicine
  • Health Care Service and Management, Health Policy and Services and Health Economy

Keywords

  • Acute Coronary Syndrome
  • Artificial Neural Network
  • Cardiology
  • Emergency Medicine
  • Oxygen Therapy
  • ST Elevation Myocardial Infarction

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