Presence of GAD-antibodies during gestational diabetes predicts type 1 diabetes.

Charlotta Nilsson, Dag Ursing, Carina Törn, Anders E Åberg, Mona Landin-Olsson

Research output: Contribution to journalArticlepeer-review

47 Citations (SciVal)

Abstract

OBJECTIVE - we sought to study the frequency of P-cell-specific autoantibody markers in women with gestational diabetes mellitus (GDM) and to follow these women to estimate the risk of later development of type I diabetes. RESEARCH DESIGN AND METHODS - Of 385 pregnant women with GDM during 1995-2005 in the district of Lund, 24 (6%) women were found positive for at least one of the following: islet cell antibody (ICA), GAD antibody (GADA), or tyrosine phosphatase antibody(IA-2A). The women were followed and autoantibodies reanalyzed. Those who had not developed diabetes did an oral glucose tolerance test. The frequencies of known risk factors; for GD were compared in women with GDM with and without pancreatic autoantibodies. RESULTS - Among the autoantibody-positive women, 50% had developed type I diabetes compared with none among the GDM control subjects (P = 0. 00 1), 2 1 % had impaired fasting glucose or impaired glucose tolerance compared with 12.5% among control subjects (P = 0.3), and none had developed type 2 diabetes compared with 12.5% among control subjects (P 0.1). CONCLUSIONS - Autoantibody screening in pregnant women with GDM and follow-up after delivery should be considered for early recognition of type I diabetes.
Original languageEnglish
Pages (from-to)1968-1971
JournalDiabetes Care
Volume30
Issue number8
DOIs
Publication statusPublished - 2007

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Department of Obstetrics and Gynaecology (Lund) (013018000), Diabetes and Endocrinology (013241530), Medicine (Lund) (013230025), Section I-II (013230011), Pediatrics/Urology/Gynecology/Endocrinology (013240400), Division V (013230900), Diabetes and Celiac Unit (013241540)

Subject classification (UKÄ)

  • Endocrinology and Diabetes

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