Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.

Willemijn J Jansen; Rik Ossenkoppele; Dirk L Knol; Betty M Tijms; Philip Scheltens; Frans R J Verhey; Pieter Jelle Visser; Pauline Aalten; Dag Aarsland; Daniel Alcolea; Myriam Alexander; Ina S Almdahl; Steven E Arnold; Inês Baldeiras; Henryk Barthel; Bart N M van Berckel; Kristen Bibeau; Kaj Blennow; David J Brooks; Mark A van Buchem; Vincent Camus; Enrica Cavedo; Kewei Chen; Gael Chetelat; Ann D Cohen; Alexander Drzezga; Sebastiaan Engelborghs; Anne M Fagan; Tormod Fladby; Adam S Fleisher; Wiesje M van der Flier; Lisa Ford; Stefan Förster; Juan Fortea; Nadia Foskett; Kristian S Frederiksen; Yvonne Freund-Levi; Giovanni B Frisoni; Lutz Froelich; Tomasz Gabryelewicz; Kiran Dip Gill; Olymbia Gkatzima; Estrella Gómez-Tortosa; Mark Forrest Gordon; Timo Grimmer; Harald Hampel; Lucrezia Hausner; Sabine Hellwig; Sanna-Kaisa Herukka; Helmut Hildebrandt; Lianna Ishihara; Adrian Ivanoiu; William J Jagust; Peter Johannsen; Ramesh Kandimalla; Elisabeth Kapaki; Aleksandra Klimkowicz-Mrowiec; William E Klunk; Sebastian Köhler; Norman Koglin; Johannes Kornhuber; Milica G Kramberger; Koen Van Laere; Susan M Landau; Dong Young Lee; Mony de Leon; Viviana Lisetti; Alberto Lleó; Karine Madsen; Wolfgang Maier; Jan Marcusson; Niklas Mattsson; Alexandre de Mendonça; Olga Meulenbroek; Philipp T Meyer; Mark A Mintun; Vincent Mok; José Luis Molinuevo; Hanne M Møllergård; John C Morris; Barbara Mroczko; Stefan Van der Mussele; Duk L Na; Andrew Newberg; Agneta Nordberg; Arto Nordlund; Gerald P Novak; George P Paraskevas; Lucilla Parnetti; Gayan Perera; Oliver Peters; Julius Popp; Sudesh Prabhakar; Gil D Rabinovici; Inez H G B Ramakers; Lorena Rami; Catarina Resende de Oliveira; Juha O Rinne; Karen M Rodrigue; Eloy Rodríguez-Rodríguez; Catherine M Roe; Uros Rot; Christopher C Rowe; Eckart Rüther; Osama Sabri; Páscual Sanchez-Juan; Isabel Santana; Marie Sarazin; Johannes Schröder; Christin Schütte; Sang W Seo; Femke Soetewey; Hilkka Soininen; Luiza Spiru; Hanne Struyfs; Charlotte E Teunissen; Magda Tsolaki; Rik Vandenberghe; Marcel M Verbeek; Victor L Villemagne; Stephanie J B Vos; Linda J C van Waalwijk van Doorn; Gunhild Waldemar; Anders Wallin; Åsa Wallin; Jens Wiltfang; David A Wolk; Marzena Zboch; Henrik Zetterberg

doi:10.1001/jama.2015.4668

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.

Willemijn J Jansen, Rik Ossenkoppele, Dirk L Knol, Betty M Tijms, Philip Scheltens, Frans R J Verhey, Pieter Jelle Visser, Pauline Aalten, Dag Aarsland, Daniel Alcolea, Myriam Alexander, Ina S Almdahl, Steven E Arnold, Inês Baldeiras, Henryk Barthel, Bart N M van Berckel, Kristen Bibeau, Kaj Blennow, David J Brooks, Mark A van BuchemVincent Camus, Enrica Cavedo, Kewei Chen, Gael Chetelat, Ann D Cohen, Alexander Drzezga, Sebastiaan Engelborghs, Anne M Fagan, Tormod Fladby, Adam S Fleisher, Wiesje M van der Flier, Lisa Ford, Stefan Förster, Juan Fortea, Nadia Foskett, Kristian S Frederiksen, Yvonne Freund-Levi, Giovanni B Frisoni, Lutz Froelich, Tomasz Gabryelewicz, Kiran Dip Gill, Olymbia Gkatzima, Estrella Gómez-Tortosa, Mark Forrest Gordon, Timo Grimmer, Harald Hampel, Lucrezia Hausner, Sabine Hellwig, Sanna-Kaisa Herukka, Helmut Hildebrandt, Lianna Ishihara, Adrian Ivanoiu, William J Jagust, Peter Johannsen, Ramesh Kandimalla, Elisabeth Kapaki, Aleksandra Klimkowicz-Mrowiec, William E Klunk, Sebastian Köhler, Norman Koglin, Johannes Kornhuber, Milica G Kramberger, Koen Van Laere, Susan M Landau, Dong Young Lee, Mony de Leon, Viviana Lisetti, Alberto Lleó, Karine Madsen, Wolfgang Maier, Jan Marcusson, Niklas Mattsson, Alexandre de Mendonça, Olga Meulenbroek, Philipp T Meyer, Mark A Mintun, Vincent Mok, José Luis Molinuevo, Hanne M Møllergård, John C Morris, Barbara Mroczko, Stefan Van der Mussele, Duk L Na, Andrew Newberg, Agneta Nordberg, Arto Nordlund, Gerald P Novak, George P Paraskevas, Lucilla Parnetti, Gayan Perera, Oliver Peters, Julius Popp, Sudesh Prabhakar, Gil D Rabinovici, Inez H G B Ramakers, Lorena Rami, Catarina Resende de Oliveira, Juha O Rinne, Karen M Rodrigue, Eloy Rodríguez-Rodríguez, Catherine M Roe, Uros Rot, Christopher C Rowe, Eckart Rüther, Osama Sabri, Páscual Sanchez-Juan, Isabel Santana, Marie Sarazin, Johannes Schröder, Christin Schütte, Sang W Seo, Femke Soetewey, Hilkka Soininen, Luiza Spiru, Hanne Struyfs, Charlotte E Teunissen, Magda Tsolaki, Rik Vandenberghe, Marcel M Verbeek, Victor L Villemagne, Stephanie J B Vos, Linda J C van Waalwijk van Doorn, Gunhild Waldemar, Anders Wallin, Åsa Wallin, Jens Wiltfang, David A Wolk, Marzena Zboch, Henrik Zetterberg

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Abstract

Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.

Original language	English
Pages (from-to)	1924-1938
Journal	JAMA: The Journal of the American Medical Association
Volume	313
Issue number	19
DOIs	https://doi.org/10.1001/jama.2015.4668
Publication status	Published - 2015

Subject classification (UKÄ)

Neurology

Free keywords

Amyloid beta-Peptides: analysis
Apolipoprotein E4: genetics
Biological Markers: analysis
Brain: pathology
Cerebrospinal Fluid: chemistry
Dementia: pathology
Mild Cognitive Impairment: pathology

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10.1001/jama.2015.4668

AMA_Jansen_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25988462?dopt=Abstract

Cite this

Jansen, W. J., Ossenkoppele, R., Knol, D. L., Tijms, B. M., Scheltens, P., Verhey, F. R. J., Visser, P. J., Aalten, P., Aarsland, D., Alcolea, D., Alexander, M., Almdahl, I. S., Arnold, S. E., Baldeiras, I., Barthel, H., van Berckel, B. N. M., Bibeau, K., Blennow, K., Brooks, D. J., ... Zetterberg, H. (2015). Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis. JAMA: The Journal of the American Medical Association, 313(19), 1924-1938. https://doi.org/10.1001/jama.2015.4668

@article{47e3f210d8b142e3b41d96583ba93671,

title = "Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.",

abstract = "Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.",

keywords = "Amyloid beta-Peptides: analysis, Apolipoprotein E4: genetics, Biological Markers: analysis, Brain: pathology, Cerebrospinal Fluid: chemistry, Dementia: pathology, Mild Cognitive Impairment: pathology",

author = "Jansen, {Willemijn J} and Rik Ossenkoppele and Knol, {Dirk L} and Tijms, {Betty M} and Philip Scheltens and Verhey, {Frans R J} and Visser, {Pieter Jelle} and Pauline Aalten and Dag Aarsland and Daniel Alcolea and Myriam Alexander and Almdahl, {Ina S} and Arnold, {Steven E} and In{\^e}s Baldeiras and Henryk Barthel and {van Berckel}, {Bart N M} and Kristen Bibeau and Kaj Blennow and Brooks, {David J} and {van Buchem}, {Mark A} and Vincent Camus and Enrica Cavedo and Kewei Chen and Gael Chetelat and Cohen, {Ann D} and Alexander Drzezga and Sebastiaan Engelborghs and Fagan, {Anne M} and Tormod Fladby and Fleisher, {Adam S} and {van der Flier}, {Wiesje M} and Lisa Ford and Stefan F{\"o}rster and Juan Fortea and Nadia Foskett and Frederiksen, {Kristian S} and Yvonne Freund-Levi and Frisoni, {Giovanni B} and Lutz Froelich and Tomasz Gabryelewicz and Gill, {Kiran Dip} and Olymbia Gkatzima and Estrella G{\'o}mez-Tortosa and Gordon, {Mark Forrest} and Timo Grimmer and Harald Hampel and Lucrezia Hausner and Sabine Hellwig and Sanna-Kaisa Herukka and Helmut Hildebrandt and Lianna Ishihara and Adrian Ivanoiu and Jagust, {William J} and Peter Johannsen and Ramesh Kandimalla and Elisabeth Kapaki and Aleksandra Klimkowicz-Mrowiec and Klunk, {William E} and Sebastian K{\"o}hler and Norman Koglin and Johannes Kornhuber and Kramberger, {Milica G} and {Van Laere}, Koen and Landau, {Susan M} and Lee, {Dong Young} and {de Leon}, Mony and Viviana Lisetti and Alberto Lle{\'o} and Karine Madsen and Wolfgang Maier and Jan Marcusson and Niklas Mattsson and {de Mendon{\c c}a}, Alexandre and Olga Meulenbroek and Meyer, {Philipp T} and Mintun, {Mark A} and Vincent Mok and Molinuevo, {Jos{\'e} Luis} and M{\o}llerg{\aa}rd, {Hanne M} and Morris, {John C} and Barbara Mroczko and {Van der Mussele}, Stefan and Na, {Duk L} and Andrew Newberg and Agneta Nordberg and Arto Nordlund and Novak, {Gerald P} and Paraskevas, {George P} and Lucilla Parnetti and Gayan Perera and Oliver Peters and Julius Popp and Sudesh Prabhakar and Rabinovici, {Gil D} and Ramakers, {Inez H G B} and Lorena Rami and {Resende de Oliveira}, Catarina and Rinne, {Juha O} and Rodrigue, {Karen M} and Eloy Rodr{\'i}guez-Rodr{\'i}guez and Roe, {Catherine M} and Uros Rot and Rowe, {Christopher C} and Eckart R{\"u}ther and Osama Sabri and P{\'a}scual Sanchez-Juan and Isabel Santana and Marie Sarazin and Johannes Schr{\"o}der and Christin Sch{\"u}tte and Seo, {Sang W} and Femke Soetewey and Hilkka Soininen and Luiza Spiru and Hanne Struyfs and Teunissen, {Charlotte E} and Magda Tsolaki and Rik Vandenberghe and Verbeek, {Marcel M} and Villemagne, {Victor L} and Vos, {Stephanie J B} and {van Waalwijk van Doorn}, {Linda J C} and Gunhild Waldemar and Anders Wallin and {\AA}sa Wallin and Jens Wiltfang and Wolk, {David A} and Marzena Zboch and Henrik Zetterberg",

year = "2015",

doi = "10.1001/jama.2015.4668",

language = "English",

volume = "313",

pages = "1924--1938",

journal = "JAMA: The Journal of the American Medical Association",

issn = "1538-3598",

publisher = "American Medical Association",

number = "19",

}

Jansen, WJ, Ossenkoppele, R, Knol, DL, Tijms, BM, Scheltens, P, Verhey, FRJ, Visser, PJ, Aalten, P, Aarsland, D, Alcolea, D, Alexander, M, Almdahl, IS, Arnold, SE, Baldeiras, I, Barthel, H, van Berckel, BNM, Bibeau, K, Blennow, K, Brooks, DJ, van Buchem, MA, Camus, V, Cavedo, E, Chen, K, Chetelat, G, Cohen, AD, Drzezga, A, Engelborghs, S, Fagan, AM, Fladby, T, Fleisher, AS, van der Flier, WM, Ford, L, Förster, S, Fortea, J, Foskett, N, Frederiksen, KS, Freund-Levi, Y, Frisoni, GB, Froelich, L, Gabryelewicz, T, Gill, KD, Gkatzima, O, Gómez-Tortosa, E, Gordon, MF, Grimmer, T, Hampel, H, Hausner, L, Hellwig, S, Herukka, S-K, Hildebrandt, H, Ishihara, L, Ivanoiu, A, Jagust, WJ, Johannsen, P, Kandimalla, R, Kapaki, E, Klimkowicz-Mrowiec, A, Klunk, WE, Köhler, S, Koglin, N, Kornhuber, J, Kramberger, MG, Van Laere, K, Landau, SM, Lee, DY, de Leon, M, Lisetti, V, Lleó, A, Madsen, K, Maier, W, Marcusson, J, Mattsson, N, de Mendonça, A, Meulenbroek, O, Meyer, PT, Mintun, MA, Mok, V, Molinuevo, JL, Møllergård, HM, Morris, JC, Mroczko, B, Van der Mussele, S, Na, DL, Newberg, A, Nordberg, A, Nordlund, A, Novak, GP, Paraskevas, GP, Parnetti, L, Perera, G, Peters, O, Popp, J, Prabhakar, S, Rabinovici, GD, Ramakers, IHGB, Rami, L, Resende de Oliveira, C, Rinne, JO, Rodrigue, KM, Rodríguez-Rodríguez, E, Roe, CM, Rot, U, Rowe, CC, Rüther, E, Sabri, O, Sanchez-Juan, P, Santana, I, Sarazin, M, Schröder, J, Schütte, C, Seo, SW, Soetewey, F, Soininen, H, Spiru, L, Struyfs, H, Teunissen, CE, Tsolaki, M, Vandenberghe, R, Verbeek, MM, Villemagne, VL, Vos, SJB, van Waalwijk van Doorn, LJC, Waldemar, G, Wallin, A, Wallin, Å, Wiltfang, J, Wolk, DA, Zboch, M & Zetterberg, H 2015, 'Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.', JAMA: The Journal of the American Medical Association, vol. 313, no. 19, pp. 1924-1938. https://doi.org/10.1001/jama.2015.4668

TY - JOUR

T1 - Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.

AU - Jansen, Willemijn J

AU - Ossenkoppele, Rik

AU - Knol, Dirk L

AU - Tijms, Betty M

AU - Scheltens, Philip

AU - Verhey, Frans R J

AU - Visser, Pieter Jelle

AU - Aalten, Pauline

AU - Aarsland, Dag

AU - Alcolea, Daniel

AU - Alexander, Myriam

AU - Almdahl, Ina S

AU - Arnold, Steven E

AU - Baldeiras, Inês

AU - Barthel, Henryk

AU - van Berckel, Bart N M

AU - Bibeau, Kristen

AU - Blennow, Kaj

AU - Brooks, David J

AU - van Buchem, Mark A

AU - Camus, Vincent

AU - Cavedo, Enrica

AU - Chen, Kewei

AU - Chetelat, Gael

AU - Cohen, Ann D

AU - Drzezga, Alexander

AU - Engelborghs, Sebastiaan

AU - Fagan, Anne M

AU - Fladby, Tormod

AU - Fleisher, Adam S

AU - van der Flier, Wiesje M

AU - Ford, Lisa

AU - Förster, Stefan

AU - Fortea, Juan

AU - Foskett, Nadia

AU - Frederiksen, Kristian S

AU - Freund-Levi, Yvonne

AU - Frisoni, Giovanni B

AU - Froelich, Lutz

AU - Gabryelewicz, Tomasz

AU - Gill, Kiran Dip

AU - Gkatzima, Olymbia

AU - Gómez-Tortosa, Estrella

AU - Gordon, Mark Forrest

AU - Grimmer, Timo

AU - Hampel, Harald

AU - Hausner, Lucrezia

AU - Hellwig, Sabine

AU - Herukka, Sanna-Kaisa

AU - Hildebrandt, Helmut

AU - Ishihara, Lianna

AU - Ivanoiu, Adrian

AU - Jagust, William J

AU - Johannsen, Peter

AU - Kandimalla, Ramesh

AU - Kapaki, Elisabeth

AU - Klimkowicz-Mrowiec, Aleksandra

AU - Klunk, William E

AU - Köhler, Sebastian

AU - Koglin, Norman

AU - Kornhuber, Johannes

AU - Kramberger, Milica G

AU - Van Laere, Koen

AU - Landau, Susan M

AU - Lee, Dong Young

AU - de Leon, Mony

AU - Lisetti, Viviana

AU - Lleó, Alberto

AU - Madsen, Karine

AU - Maier, Wolfgang

AU - Marcusson, Jan

AU - Mattsson, Niklas

AU - de Mendonça, Alexandre

AU - Meulenbroek, Olga

AU - Meyer, Philipp T

AU - Mintun, Mark A

AU - Mok, Vincent

AU - Molinuevo, José Luis

AU - Møllergård, Hanne M

AU - Morris, John C

AU - Mroczko, Barbara

AU - Van der Mussele, Stefan

AU - Na, Duk L

AU - Newberg, Andrew

AU - Nordberg, Agneta

AU - Nordlund, Arto

AU - Novak, Gerald P

AU - Paraskevas, George P

AU - Parnetti, Lucilla

AU - Perera, Gayan

AU - Peters, Oliver

AU - Popp, Julius

AU - Prabhakar, Sudesh

AU - Rabinovici, Gil D

AU - Ramakers, Inez H G B

AU - Rami, Lorena

AU - Resende de Oliveira, Catarina

AU - Rinne, Juha O

AU - Rodrigue, Karen M

AU - Rodríguez-Rodríguez, Eloy

AU - Roe, Catherine M

AU - Rot, Uros

AU - Rowe, Christopher C

AU - Rüther, Eckart

AU - Sabri, Osama

AU - Sanchez-Juan, Páscual

AU - Santana, Isabel

AU - Sarazin, Marie

AU - Schröder, Johannes

AU - Schütte, Christin

AU - Seo, Sang W

AU - Soetewey, Femke

AU - Soininen, Hilkka

AU - Spiru, Luiza

AU - Struyfs, Hanne

AU - Teunissen, Charlotte E

AU - Tsolaki, Magda

AU - Vandenberghe, Rik

AU - Verbeek, Marcel M

AU - Villemagne, Victor L

AU - Vos, Stephanie J B

AU - van Waalwijk van Doorn, Linda J C

AU - Waldemar, Gunhild

AU - Wallin, Anders

AU - Wallin, Åsa

AU - Wiltfang, Jens

AU - Wolk, David A

AU - Zboch, Marzena

AU - Zetterberg, Henrik

PY - 2015

Y1 - 2015

N2 - Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.

AB - Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.

KW - Amyloid beta-Peptides: analysis

KW - Apolipoprotein E4: genetics

KW - Biological Markers: analysis

KW - Brain: pathology

KW - Cerebrospinal Fluid: chemistry

KW - Dementia: pathology

KW - Mild Cognitive Impairment: pathology

U2 - 10.1001/jama.2015.4668

DO - 10.1001/jama.2015.4668

M3 - Article

C2 - 25988462

SN - 1538-3598

VL - 313

SP - 1924

EP - 1938

JO - JAMA: The Journal of the American Medical Association

JF - JAMA: The Journal of the American Medical Association

IS - 19

ER -

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.

Abstract

Subject classification (UKÄ)

Free keywords

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