Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells.

Sara Rolandsson Enes; Annika Andersson Sjöland; Jan Claas Brune; Hongzhe Li; Moustapha Kassem; Fredrik Mertens; Albert Westergren; Leif Eriksson; Lennart Hansson; Ingrid Skog; Leif Bjermer; Stefan Scheding; Gunilla Westergren-Thorsson

doi:10.1136/bmjresp-2014-000027

Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells.

Sara Rolandsson Enes, Annika Andersson Sjöland, Jan Claas Brune, Hongzhe Li, Moustapha Kassem, Fredrik Mertens, Albert Westergren, Leif Eriksson, Lennart Hansson, Ingrid Skog, Leif Bjermer, Stefan Scheding, Gunilla Westergren-Thorsson

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Abstract

Mesenchymal stem cells (MSC) have not only been implicated in the development of lung diseases, but they have also been proposed as a future cell-based therapy for lung diseases. However, the cellular identity of the primary MSC in human lung tissues has not yet been reported. This study therefore aimed to identify and characterise the 'bona fide' MSC in human lungs and to investigate if the MSC numbers correlate with the development of bronchiolitis obliterans syndrome in lung-transplanted patients.

Original language	English
Article number	e000027
Journal	BMJ Open Respiratory Research
Volume	1
Issue number	1
DOIs	https://doi.org/10.1136/bmjresp-2014-000027
Publication status	Published - 2014

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Lung Biology (013212002), Division of Clinical Genetics (013022003), Respiratory Medicine and Allergology (013230111), Stem Cell Center (013041110), Caring Sciences (Closed 2012) (016514020)

Subject classification (UKÄ)

Cell and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/bmjresp-2014-000027Licence: CC BY

BMJ_Rolandsson_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25478178?dopt=Abstract

1 Doctoral Thesis (compilation)

Mesenchymal stromal cells in lung tissue
Rolandsson Enes, S., 2016, Lung Biology. 77 p.
Research output: Thesis › Doctoral Thesis (compilation)

Cite this

Rolandsson Enes, S., Andersson Sjöland, A., Brune, J. C., Li, H., Kassem, M., Mertens, F., Westergren, A., Eriksson, L., Hansson, L., Skog, I., Bjermer, L., Scheding, S., & Westergren-Thorsson, G. (2014). Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells. BMJ Open Respiratory Research, 1(1), Article e000027. https://doi.org/10.1136/bmjresp-2014-000027

@article{9842c6ec96e64f268820ea02ffc4fd0b,

title = "Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells.",

abstract = "Mesenchymal stem cells (MSC) have not only been implicated in the development of lung diseases, but they have also been proposed as a future cell-based therapy for lung diseases. However, the cellular identity of the primary MSC in human lung tissues has not yet been reported. This study therefore aimed to identify and characterise the 'bona fide' MSC in human lungs and to investigate if the MSC numbers correlate with the development of bronchiolitis obliterans syndrome in lung-transplanted patients.",

author = "{Rolandsson Enes}, Sara and {Andersson Sj{\"o}land}, Annika and Brune, {Jan Claas} and Hongzhe Li and Moustapha Kassem and Fredrik Mertens and Albert Westergren and Leif Eriksson and Lennart Hansson and Ingrid Skog and Leif Bjermer and Stefan Scheding and Gunilla Westergren-Thorsson",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Lung Biology (013212002), Division of Clinical Genetics (013022003), Respiratory Medicine and Allergology (013230111), Stem Cell Center (013041110), Caring Sciences (Closed 2012) (016514020)",

year = "2014",

doi = "10.1136/bmjresp-2014-000027",

language = "English",

volume = "1",

journal = "BMJ Open Respiratory Research",

issn = "2052-4439",

publisher = "BMJ Publishing Group",

number = "1",

}

Rolandsson Enes, S, Andersson Sjöland, A, Brune, JC, Li, H, Kassem, M, Mertens, F, Westergren, A, Eriksson, L, Hansson, L, Skog, I, Bjermer, L , Scheding, S & Westergren-Thorsson, G 2014, 'Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells.', BMJ Open Respiratory Research, vol. 1, no. 1, e000027. https://doi.org/10.1136/bmjresp-2014-000027

TY - JOUR

T1 - Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells.

AU - Rolandsson Enes, Sara

AU - Andersson Sjöland, Annika

AU - Brune, Jan Claas

AU - Li, Hongzhe

AU - Kassem, Moustapha

AU - Mertens, Fredrik

AU - Westergren, Albert

AU - Eriksson, Leif

AU - Hansson, Lennart

AU - Skog, Ingrid

AU - Bjermer, Leif

AU - Scheding, Stefan

AU - Westergren-Thorsson, Gunilla

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Lung Biology (013212002), Division of Clinical Genetics (013022003), Respiratory Medicine and Allergology (013230111), Stem Cell Center (013041110), Caring Sciences (Closed 2012) (016514020)

PY - 2014

Y1 - 2014

N2 - Mesenchymal stem cells (MSC) have not only been implicated in the development of lung diseases, but they have also been proposed as a future cell-based therapy for lung diseases. However, the cellular identity of the primary MSC in human lung tissues has not yet been reported. This study therefore aimed to identify and characterise the 'bona fide' MSC in human lungs and to investigate if the MSC numbers correlate with the development of bronchiolitis obliterans syndrome in lung-transplanted patients.

AB - Mesenchymal stem cells (MSC) have not only been implicated in the development of lung diseases, but they have also been proposed as a future cell-based therapy for lung diseases. However, the cellular identity of the primary MSC in human lung tissues has not yet been reported. This study therefore aimed to identify and characterise the 'bona fide' MSC in human lungs and to investigate if the MSC numbers correlate with the development of bronchiolitis obliterans syndrome in lung-transplanted patients.

U2 - 10.1136/bmjresp-2014-000027

DO - 10.1136/bmjresp-2014-000027

M3 - Article

C2 - 25478178

SN - 2052-4439

VL - 1

JO - BMJ Open Respiratory Research

JF - BMJ Open Respiratory Research

IS - 1

M1 - e000027

ER -

Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells.

Abstract

Bibliographical note

Subject classification (UKÄ)

UN SDGs

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Research output

Mesenchymal stromal cells in lung tissue

Cite this