Prognostic implications of cytogenetic aberrations in diffuse large B-cell lymphomas

Mats Jerkeman, Bertil Johansson, Måns Åkerman, Eva Cavallin-Ståhl, Ulf Kristoffersson, Felix Mitelman

Research output: Contribution to journalArticlepeer-review

24 Citations (SciVal)

Abstract

A single institution series of 81 consecutive, cytogenetically analyzed, diffuse large B-cell lymphomas (DLBL), the majority of which treated with anthracycline-containing combination chemotherapy, were reviewed retrospectively to investigate whether the karyotypic pattern or certain abnormalities correlate with survival. Clonal chromosome changes were found in 79 of the 81 cases. The prognostic impact of the following aberrations, all suggested in previous studies to be associated with either shorter or longer survival, were tested: 1q21-23 breakpoints, +2/dup(2p), +3/dup(3p), +5, +6, 6q21-25 breakpoints, monosomy 7/der(7p)/i(7q), trisomy 7, 14q11-12 breakpoints, monosomy 17/der(17p)/i(17q), trisomy 18, > 4 marker chromosomes, > 4 breakpoints, and > or = 10 abnormalities. Univariate analysis showed that a breakpoint at 1q21-23 or trisomy 6 was associated with a shorter survival. However, when adjusted for age, stage, performance status and lactate dehydrogenase level, none of the cytogenetic aberrations had an independent prognostic value. Thus, the present investigation provides no support for any of the above-mentioned abnormalities being of prognostic importance in DLBL.
Original languageEnglish
Pages (from-to)184-190
JournalEuropean Journal of Haematology
Volume62
Issue number3
Publication statusPublished - 1999

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000), Division of Clinical Genetics (013022003)

Subject classification (UKÄ)

  • Hematology

Keywords

  • B-Lymphocyte
  • Large cell lymphoma
  • Chromosomal aberration
  • Cytogenetics
  • Prognosis
  • Human
  • Non Hodgkin lymphoma
  • Lymphoproliferative syndrome
  • Malignant hemopathy
  • Genetics

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