Proliferation of the breast epithelium in relation to menstrual cycle phase, hormonal use, and reproductive factors

H Olsson, Helena Jernström, Per Alm, H Kreipe, Christian Ingvar, P E Jönsson, S Ryden

Research output: Contribution to journalArticlepeer-review


The proliferative rate in normal breast epithelium from 58 women undergoing reduction mammoplastics was studied using the formalin resistant antibody Ki-S5, and related to age at operation, menstrual cycle phase, family history of breast cancer, height and weight, parity, and hormonal use. The breast tissue from women operated on in the luteal menstrual cycle phase (day 15-28 among oral contraceptive (OC) users) had significantly higher proliferative rate than breast tissue removed from women in the follicular phase (day 1-14) (p = 0.01). Among women presently exposed to hormones, those with a positive family history of breast cancer among first and second degree relatives had significantly higher values than cases without such history (p = 0.02). Weight was not significantly related to proliferation rate, while a short height was associated with a significantly higher proliferation rate (p = 0.04). Women who used OCs before the first full-term pregnancy (FFTP) had a significantly higher proliferation rate compared with never users or late users (p = 0.04). No significant difference was seen between parous versus nulliparous women. The results from the univariate analysis persisted in multivariate models. An especially high proliferation rate was seen in young women with both a positive family history and present hormonal use (p = 0.001). Overall, it was found that young women had a non-significantly higher proliferation rate than older women (p = 0.10). Due to small sample size, these results must be regarded as preliminary, especially in the subgroup analyses.
Original languageEnglish
Pages (from-to)187-196
JournalBreast Cancer Research and Treatment
Issue number2
Publication statusPublished - 1996

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Oncology, MV (013035000), Surgery (Lund) (013009000), Pathology, (Lund) (013030000)

Subject classification (UKÄ)

  • Cancer and Oncology

Free keywords

  • benign breast
  • family history
  • Ki-S5
  • menstrual cycle phase
  • proliferation


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