Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

R F Schelbergen; E J Geven; M H J van den Bosch; H Eriksson; Tomas Leanderson; T Vogl; J Roth; F A J van de Loo; M I Koenders; P M van der Kraan; W B van den Berg; A B Blom; P L E M van Lent

doi:10.1136/annrheumdis-2014-206517

Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

R F Schelbergen, E J Geven, M H J van den Bosch, H Eriksson, Tomas Leanderson, T Vogl, J Roth, F A J van de Loo, M I Koenders, P M van der Kraan, W B van den Berg, A B Blom, P L E M van Lent

Research output: Contribution to journal › Article › peer-review

Abstract

Alarmins S100A8/A9 regulate pathology in experimental osteoarthritis (OA). Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. We investigated the effect of paquinimod on experimental OA and human OA synovium.

Original language	English
Pages (from-to)	2254-2258
Journal	Annals of the Rheumatic Diseases
Volume	74
Issue number	12
DOIs	https://doi.org/10.1136/annrheumdis-2014-206517
Publication status	Published - 2015

Subject classification (UKÄ)

Rheumatology and Autoimmunity

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10.1136/annrheumdis-2014-206517

http://www.ncbi.nlm.nih.gov/pubmed/25969431?dopt=Abstract

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Schelbergen, R. F., Geven, E. J., van den Bosch, M. H. J., Eriksson, H., Leanderson, T., Vogl, T., Roth, J., van de Loo, F. A. J., Koenders, M. I., van der Kraan, P. M., van den Berg, W. B., Blom, A. B., & van Lent, P. L. E. M. (2015). Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Annals of the Rheumatic Diseases, 74(12), 2254-2258. https://doi.org/10.1136/annrheumdis-2014-206517

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title = "Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.",

abstract = "Alarmins S100A8/A9 regulate pathology in experimental osteoarthritis (OA). Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. We investigated the effect of paquinimod on experimental OA and human OA synovium.",

author = "Schelbergen, {R F} and Geven, {E J} and {van den Bosch}, {M H J} and H Eriksson and Tomas Leanderson and T Vogl and J Roth and {van de Loo}, {F A J} and Koenders, {M I} and {van der Kraan}, {P M} and {van den Berg}, {W B} and Blom, {A B} and {van Lent}, {P L E M}",

year = "2015",

doi = "10.1136/annrheumdis-2014-206517",

language = "English",

volume = "74",

pages = "2254--2258",

journal = "Annals of the Rheumatic Diseases",

issn = "1468-2060",

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Schelbergen, RF, Geven, EJ, van den Bosch, MHJ, Eriksson, H, Leanderson, T, Vogl, T, Roth, J, van de Loo, FAJ, Koenders, MI, van der Kraan, PM, van den Berg, WB, Blom, AB & van Lent, PLEM 2015, 'Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.', Annals of the Rheumatic Diseases, vol. 74, no. 12, pp. 2254-2258. https://doi.org/10.1136/annrheumdis-2014-206517

TY - JOUR

T1 - Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

AU - Schelbergen, R F

AU - Geven, E J

AU - van den Bosch, M H J

AU - Eriksson, H

AU - Leanderson, Tomas

AU - Vogl, T

AU - Roth, J

AU - van de Loo, F A J

AU - Koenders, M I

AU - van der Kraan, P M

AU - van den Berg, W B

AU - Blom, A B

AU - van Lent, P L E M

PY - 2015

Y1 - 2015

N2 - Alarmins S100A8/A9 regulate pathology in experimental osteoarthritis (OA). Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. We investigated the effect of paquinimod on experimental OA and human OA synovium.

AB - Alarmins S100A8/A9 regulate pathology in experimental osteoarthritis (OA). Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. We investigated the effect of paquinimod on experimental OA and human OA synovium.

U2 - 10.1136/annrheumdis-2014-206517

DO - 10.1136/annrheumdis-2014-206517

M3 - Article

C2 - 25969431

SN - 1468-2060

VL - 74

SP - 2254

EP - 2258

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

IS - 12

ER -

Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

Abstract

Subject classification (UKÄ)

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