Prostaglandin E(2) and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: No impact on survival of seizure-generated neurons.

Maria Antonietta Ajmone-Cat, Robert Iosif, Christine Ekdahl Clementson, Zaal Kokaia, Luisa Minghetti, Olle Lindvall

Research output: Contribution to journalArticlepeer-review

15 Citations (SciVal)

Abstract

Partial and generalized status epilepticus (pSE and gSE) trigger the same level of progenitor cell proliferation in adult dentate gyrus, but survival of new neurons is poor after gSE. Here, we show markedly elevated levels of prostaglandin E-2 (PGE(2)) and brain-derived neurotrophic factor (BDNF) in rat hippocampal formation at 7 days following pSE but not gSE. Administration of the cyclooxygenase (COX) inhibitor flurbiprofen for 1 week, starting at day 8 post-SE, abated PGE(2) and decreased BDNF levels, but did not affect survival of new neurons a weeks later. Thus, high PGE(2) and BDNF levels induced by pSE are probably not of major importance for survival of new neurons during the first days after formation. We propose that they modulate other aspects of synaptic and cellular plasticity, and thereby may influence epileptogenesis.
Original languageEnglish
Pages (from-to)23-35
JournalNeurobiology of Disease
Volume23
Issue number1
DOIs
Publication statusPublished - 2006

Subject classification (UKÄ)

  • Neurosciences

Keywords

  • status epilepticus
  • flurbiprofen
  • neurogenesis
  • isoprostanes
  • EP3
  • EP2
  • neurotrophic factor (BDNF)
  • brain-derived
  • prostaglandin E-2 (PGE(2))
  • cyclooxygenase-2 (COX-2)

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