Prostate cancer as a first and second cancer: effect of family history

H. Zhang, J. L. Bermejo, Jan Sundquist, K. Hemminki

Research output: Contribution to journalArticlepeer-review

5 Citations (SciVal)

Abstract

BACKGROUND: Diagnosis with prostate cancer has been reported to increase the risk of subsequent tumours. However, specific data on individuals with a parental history are not available so far. METHODS: On the basis of the nationwide Swedish Family-Cancer Database including 18,207 primary invasive prostate cancers, standardised incidence ratios (SIRs) were used to estimate the relative risks of subsequent tumours after prostate cancer in the general population and among individuals with a parental history of cancer. RESULTS: A significantly increased SIR of colorectal cancer was found among prostate cancer patients with a parental history of colorectal cancer (2.26, 11 cases). The SIRs of parental concordant ( same site) tumours after prostate cancer were also increased for urinary bladder cancer (4.42, 4 cases) and chronic lymphoid leukaemia (38.0, 2 cases). CONCLUSION: A higher than additive and multiplicative interaction was observed between the individual history of prostate cancer and parental history of colorectal and urinary bladder cancers, although the number of cases did not permit the rejection of any interaction model. The results suggest that the occurrence of second tumours, for example bladder after prostate or prostate after bladder tumours, is mostly related to shared genetic and non-genetic risk factors rather than treatment of first cancer. British Journal of Cancer ( 2009) 101, 935-939. doi:10.1038/sj.bjc.6605263 www.bjcancer.com Published online 18 August 2009 (C) 2009 Cancer Research UK
Original languageEnglish
Pages (from-to)935-939
JournalBritish Journal of Cancer
Volume101
Issue number6
DOIs
Publication statusPublished - 2009

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Psychiatry/Primary Care/Public Health (013240500), Family medicine, psychiatric epidemiology and migration (013240037), Family Medicine (013241010)

Subject classification (UKÄ)

  • Cancer and Oncology

Keywords

  • second primary malignancy
  • familial risk
  • prostate cancer

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