Protective effects of chronic nicotine treatment on lesioned nigrostriatal dopamine neurons in the male rat

A M Janson, K Fuxe, L F Agnati, A Jansson, B Bjelke, E Sundstrom, K Andersson, A Harfstrand, M Goldstein, Christer Owman

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The present results demonstrate that chronic nicotine treatment can in part protect against mechanically-induced and neurotoxin-induced degeneration of nigrostriatal DA neurons. These results indicate that in sufficient doses chronic treatment with nicotine may be considered in the pharmacological treatment of Parkinson's disease. It remains to be demonstrated whether these protective actions can be extended to include also other injured neurons such as the cholinergic neurons, known to be severely affected in Alzheimer's disease.
    Original languageEnglish
    Pages (from-to)257-265
    JournalProgress in Brain Research
    Volume79
    Publication statusPublished - 1989

    Subject classification (UKÄ)

    • Neurosciences

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