Protein kinase C and the regulation of the actin cytoskeleton.

Research output: Contribution to journalReview articlepeer-review

267 Citations (SciVal)

Abstract

Protein kinase C (PKC) isoforms are central components in intracellular networks that regulate a vast number of cellular processes. It has long been known that in most cell types, one or more PKC isoforms influences the morphology of the F-actin cytoskeleton and thereby regulates processes that are affected by remodelling of the microfilaments. These include cellular migration and neurite outgrowth. This review focuses on the role of classical and novel PKC isoforms in migration and neurite outgrowth, and highlights some regulatory steps that may be of importance in the regulation by PKC of migration and neurite outgrowth. Many studies indicate that integrins are crucial mediators both upstream and downstream of PKC in inducing morphological changes. Furthermore, a number of PKC substrates, directly associated with the microfilaments, such as MARCKS, GAP43, adducin, fascin, ERM proteins and others have been identified. Their potential role in PKC effects on the cytoskeleton is discussed.
Original languageEnglish
Pages (from-to)276-284
JournalCellular Signalling
Volume18
Issue number3
DOIs
Publication statusPublished - 2006

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Tumour Cell Biology (013017530)

Subject classification (UKÄ)

  • Microbiology

Keywords

  • fibers
  • integrins
  • cell movement
  • neurite
  • stress
  • protein kinase C
  • actin

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