Abstract
Adult mice sensory ganglia were cultured in an extracellular matrix gel. Analyses of extending axons were made 48 h (long-term) or immediately (short-term) after addition of protein kinase inhibitors. Long- and short-term growth was insensitive to protein kinase A/G inhibition by HA-1004. Long-term protein kinase C inhibition by chelerythrine affected only certain, long axons. In the short-term virtually all axon growth was arrested, but largely recovered on the following day. When combined, the drugs inhibited all long- and short-term growth and largely prevented the recovery of the latter. The transient effect by chelerythrine, and the permanent inhibition after combination with HA-1004, suggests compensatory mechanisms, perhaps via other kinases. Copyright (C) 1999 Elsevier Science Ireland Ltd.
Original language | English |
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Pages (from-to) | 155-158 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 275 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1999 Nov 19 |
Subject classification (UKÄ)
- Cell Biology
Free keywords
- Chelerythrine chloride
- Dorsal root ganglia
- Growth cones
- HA-1004
- Protein kinase A
- Protein kinase G