Protein kinase C modulation of the ethanol effect on serotonin2 receptor transduction in astrocytes

Per Simonsson, Elisabeth Hansson, Christer Alling

Research output: Contribution to journalArticlepeer-review

Abstract

Acute ethanol exposure stimulated serotonin2 receptor signalling in cultured astrocytes. Pretreatment with the protein kinase C inhibitor H7 significantly increased the ethanol-induced potentiation of [3H]-inositol phosphates accumulation. The increase could be explained by an augmented activation of phospholipase C. The results indicate a role of PKC for the modulation of ethanol effects on cellular signalling.
Original languageEnglish
Pages (from-to)401-404
JournalAlcohol and Alcoholism
Volume24
Issue number5
Publication statusPublished - 1989

Subject classification (UKÄ)

  • Substance Abuse

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