Protein S and factor V in regulation of coagulation on platelet microparticles by activated protein C.

Sofia Somajo; Ruzica Livaja Koshiar; Eva Norström; Björn Dahlbäck

doi:10.1016/j.thromres.2014.04.031

Protein S and factor V in regulation of coagulation on platelet microparticles by activated protein C.

Sofia Somajo, Ruzica Livaja Koshiar, Eva Norström, Björn Dahlbäck

Clinical Chemistry, Malmö

Research output: Contribution to journal › Article › peer-review

Abstract

Platelets are the main source of microparticles in plasma and the concentration of microparticles is increased in many diseases. As microparticles expose negatively charged phospholipids, they can bind and assemble the procoagulant enzyme-cofactor complexes. Our aim was to elucidate possible regulation of these complexes on microparticles by the anticoagulant protein C system.

Original language	English
Pages (from-to)	144-152
Journal	Thrombosis Research
Volume	134
Issue number	1
DOIs	https://doi.org/10.1016/j.thromres.2014.04.031
Publication status	Published - 2014

Subject classification (UKÄ)

Cardiac and Cardiovascular Systems

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10.1016/j.thromres.2014.04.031

http://www.ncbi.nlm.nih.gov/pubmed/24835672?dopt=Abstract

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@article{4a353319cd5c4c41af03747ec60029af,

title = "Protein S and factor V in regulation of coagulation on platelet microparticles by activated protein C.",

abstract = "Platelets are the main source of microparticles in plasma and the concentration of microparticles is increased in many diseases. As microparticles expose negatively charged phospholipids, they can bind and assemble the procoagulant enzyme-cofactor complexes. Our aim was to elucidate possible regulation of these complexes on microparticles by the anticoagulant protein C system.",

author = "Sofia Somajo and {Livaja Koshiar}, Ruzica and Eva Norstr{\"o}m and Bj{\"o}rn Dahlb{\"a}ck",

year = "2014",

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journal = "Thrombosis Research",

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AU - Somajo, Sofia

AU - Livaja Koshiar, Ruzica

AU - Norström, Eva

AU - Dahlbäck, Björn

PY - 2014

Y1 - 2014

N2 - Platelets are the main source of microparticles in plasma and the concentration of microparticles is increased in many diseases. As microparticles expose negatively charged phospholipids, they can bind and assemble the procoagulant enzyme-cofactor complexes. Our aim was to elucidate possible regulation of these complexes on microparticles by the anticoagulant protein C system.

AB - Platelets are the main source of microparticles in plasma and the concentration of microparticles is increased in many diseases. As microparticles expose negatively charged phospholipids, they can bind and assemble the procoagulant enzyme-cofactor complexes. Our aim was to elucidate possible regulation of these complexes on microparticles by the anticoagulant protein C system.

U2 - 10.1016/j.thromres.2014.04.031

DO - 10.1016/j.thromres.2014.04.031

M3 - Article

C2 - 24835672

VL - 134

SP - 144

EP - 152

JO - Thrombosis Research

JF - Thrombosis Research

SN - 1879-2472

IS - 1

ER -

Protein S and factor V in regulation of coagulation on platelet microparticles by activated protein C.

Abstract

Subject classification (UKÄ)

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