Protein Z and protein Z-dependent protease inhibitor - Determinants of levels and risk of venous thrombosis

A Al-Shanqeeti, AV Vlieg, Erik Berntorp, FR Rosendaal, GJ Broze

Research output: Contribution to journalArticlepeer-review

55 Citations (SciVal)

Abstract

To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.
Original languageEnglish
Pages (from-to)411-413
JournalThrombosis and Haemostasis
Volume93
Issue number3
DOIs
Publication statusPublished - 2005

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems

Keywords

  • thrombophilia
  • coagulation inhibitors
  • clinical/epidemiological studies

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