Proteome

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Abstract

Proteomics can be defined as the studies of protein properties on a large scale to obtain a global view of biological processes at the protein level. Essentially, proteomics requires protein separation and identification, and in many cases quantification. The cornerstones in proteomics are protein/peptide separation by gel electrophoresis and/or different chromatographic techniques, and identification by mass spectrometry followed by bioinformatic and biological interpretation of data. By combining these different separation techniques and mass spectrometry it is now possible to identify low abundant proteins with 10-1000 copies per cell. Today, substantial research efforts in proteome studies of the lung are focused on obtaining new diagnostic markers, as well as fingerprinting disease mechanisms.

Original languageEnglish
Title of host publicationEncyclopedia of Respiratory Medicine, Four-Volume Set
PublisherElsevier
Pages527-532
ISBN (Print)9780123708793
DOIs
Publication statusPublished - 2006 Jan 1

Subject classification (UKÄ)

  • Medical Genetics

Keywords

  • Bioinformatics
  • Broncheoalveolar lavage
  • Fibroblasts
  • Gel electrophoresis
  • Gene ontology
  • Lung
  • Mass spectrometry
  • Peptides
  • Protein
  • Proteome

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