Purkinje Neurons During Eye Blink Conditioning and New Mechanisms of Cerebellar Learning and Timing

Germund Hesslow; Dan Anders Jirenhed; Fredrik Johansson

doi:10.1007/978-3-030-23810-0_115

Purkinje Neurons During Eye Blink Conditioning and New Mechanisms of Cerebellar Learning and Timing

Germund Hesslow, Dan Anders Jirenhed, Fredrik Johansson

Associative Learning

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Abstract

During eyeblink conditioning, Purkinje cells that control blinking develop an inhibitory response to the conditional stimulus. This conditional response (CR) in the Purkinje cell shows a number of striking similarities to the overt blink CR, including adaptive timing. The evidence suggests that the Purkinje cell CR drives the overt CR. Recent results show that the Purkinje cell CR does not depend on long-term depression but on a novel mechanism that enables the cell to learn the temporal interval between conditional and unconditional stimuli and time of the CR accordingly.

Original language	English
Title of host publication	Handbook of the Cerebellum and Cerebellar Disorders
Subtitle of host publication	Second Edition: Volume 3
Publisher	Springer International Publishing
Pages	1335-1344
Number of pages	10
ISBN (Electronic)	9783030238100
ISBN (Print)	9783030238094
DOIs	https://doi.org/10.1007/978-3-030-23810-0_115
Publication status	Published - 2021

Subject classification (UKÄ)

Neurosciences

Free keywords

Cerebellum
Classical conditioning
Purkinje cells
Simple spikes
Timing

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10.1007/978-3-030-23810-0_115

Cite this

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abstract = "During eyeblink conditioning, Purkinje cells that control blinking develop an inhibitory response to the conditional stimulus. This conditional response (CR) in the Purkinje cell shows a number of striking similarities to the overt blink CR, including adaptive timing. The evidence suggests that the Purkinje cell CR drives the overt CR. Recent results show that the Purkinje cell CR does not depend on long-term depression but on a novel mechanism that enables the cell to learn the temporal interval between conditional and unconditional stimuli and time of the CR accordingly.",

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Purkinje Neurons During Eye Blink Conditioning and New Mechanisms of Cerebellar Learning and Timing. / Hesslow, Germund; Jirenhed, Dan Anders; Johansson, Fredrik.
Handbook of the Cerebellum and Cerebellar Disorders: Second Edition: Volume 3. Springer International Publishing, 2021. p. 1335-1344.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

TY - CHAP

T1 - Purkinje Neurons During Eye Blink Conditioning and New Mechanisms of Cerebellar Learning and Timing

AU - Hesslow, Germund

AU - Jirenhed, Dan Anders

AU - Johansson, Fredrik

PY - 2021

Y1 - 2021

N2 - During eyeblink conditioning, Purkinje cells that control blinking develop an inhibitory response to the conditional stimulus. This conditional response (CR) in the Purkinje cell shows a number of striking similarities to the overt blink CR, including adaptive timing. The evidence suggests that the Purkinje cell CR drives the overt CR. Recent results show that the Purkinje cell CR does not depend on long-term depression but on a novel mechanism that enables the cell to learn the temporal interval between conditional and unconditional stimuli and time of the CR accordingly.

AB - During eyeblink conditioning, Purkinje cells that control blinking develop an inhibitory response to the conditional stimulus. This conditional response (CR) in the Purkinje cell shows a number of striking similarities to the overt blink CR, including adaptive timing. The evidence suggests that the Purkinje cell CR drives the overt CR. Recent results show that the Purkinje cell CR does not depend on long-term depression but on a novel mechanism that enables the cell to learn the temporal interval between conditional and unconditional stimuli and time of the CR accordingly.

KW - Cerebellum

KW - Classical conditioning

KW - Purkinje cells

KW - Simple spikes

KW - Timing

U2 - 10.1007/978-3-030-23810-0_115

DO - 10.1007/978-3-030-23810-0_115

M3 - Book chapter

AN - SCOPUS:85153661403

SN - 9783030238094

SP - 1335

EP - 1344

BT - Handbook of the Cerebellum and Cerebellar Disorders

PB - Springer International Publishing

ER -

Purkinje Neurons During Eye Blink Conditioning and New Mechanisms of Cerebellar Learning and Timing

Abstract

Subject classification (UKÄ)

Free keywords

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