PXL01 in Sodium Hyaluronate for Improvement of Hand Recovery after Flexor Tendon Repair Surgery: Randomized Controlled Trial.

Monica E Wiig; Lars Dahlin; Jan Fridén; Lars Hagberg; Sören E Larsen; Kerstin Wiklund; Margit Mahlapuu

doi:10.1371/journal.pone.0110735

PXL01 in Sodium Hyaluronate for Improvement of Hand Recovery after Flexor Tendon Repair Surgery: Randomized Controlled Trial.

Monica E Wiig, Lars Dahlin, Jan Fridén, Lars Hagberg, Sören E Larsen, Kerstin Wiklund, Margit Mahlapuu

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Abstract

Postoperative adhesions constitute a substantial clinical problem in hand surgery. Fexor tendon injury and repair result in adhesion formation around the tendon, which restricts the gliding function of the tendon, leading to decreased digit mobility and impaired hand recovery. This study evaluated the efficacy and safety of the peptide PXL01 in preventing adhesions, and correspondingly improving hand function, in flexor tendon repair surgery.

Original language	English
Article number	e110735
Journal	PLoS ONE
Volume	9
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0110735
Publication status	Published - 2014

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Hand Surgery Research Group (013241910), Reconstructive Surgery (013240300)

Subject classification (UKÄ)

Surgery

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10.1371/journal.pone.0110735

PLoS__Wiig_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25340801?dopt=Abstract

Cite this

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title = "PXL01 in Sodium Hyaluronate for Improvement of Hand Recovery after Flexor Tendon Repair Surgery: Randomized Controlled Trial.",

abstract = "Postoperative adhesions constitute a substantial clinical problem in hand surgery. Fexor tendon injury and repair result in adhesion formation around the tendon, which restricts the gliding function of the tendon, leading to decreased digit mobility and impaired hand recovery. This study evaluated the efficacy and safety of the peptide PXL01 in preventing adhesions, and correspondingly improving hand function, in flexor tendon repair surgery.",

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AU - Dahlin, Lars

AU - Fridén, Jan

AU - Hagberg, Lars

AU - Larsen, Sören E

AU - Wiklund, Kerstin

AU - Mahlapuu, Margit

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hand Surgery Research Group (013241910), Reconstructive Surgery (013240300)

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AB - Postoperative adhesions constitute a substantial clinical problem in hand surgery. Fexor tendon injury and repair result in adhesion formation around the tendon, which restricts the gliding function of the tendon, leading to decreased digit mobility and impaired hand recovery. This study evaluated the efficacy and safety of the peptide PXL01 in preventing adhesions, and correspondingly improving hand function, in flexor tendon repair surgery.

U2 - 10.1371/journal.pone.0110735

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PXL01 in Sodium Hyaluronate for Improvement of Hand Recovery after Flexor Tendon Repair Surgery: Randomized Controlled Trial.

Abstract

Bibliographical note

Subject classification (UKÄ)

Access to Document

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