Quality of Life and the Effect of Memantine in Dementia with Lewy Bodies and Parkinson's Disease Dementia.

Victoria Larsson; Knut Engedal; Dag Aarsland; Carina Wattmo; Lennart Minthon; Elisabet Londos

doi:10.1159/000334523

Quality of Life and the Effect of Memantine in Dementia with Lewy Bodies and Parkinson's Disease Dementia.

Victoria Larsson, Knut Engedal, Dag Aarsland, Carina Wattmo, Lennart Minthon, Elisabet Londos

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias. Methods: A secondary analysis of a randomized controlled study in 70 patients with Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer's disease (AD) in domains according to the WHO's classification of health. Results: Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure. Conclusion: This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL patterns which can be used in clinical practice. Copyright (C) 2011 S. Karger AG, Basel

Original language	English
Pages (from-to)	227-234
Journal	Dementia and Geriatric Cognitive Disorders
Volume	32
Issue number	4
DOIs	https://doi.org/10.1159/000334523
Publication status	Published - 2011

Subject classification (UKÄ)

Neurology

Free keywords

quality of life
Dementia
Dementia with Lewy bodies
Parkinson's
Randomized controlled trial
disease dementia

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10.1159/000334523

1 Doctoral Thesis (compilation)

Living with Lewy body dementia. Treatment, survival & quality of life.
Larsson, V., 2018, Lund: Lund University: Faculty of Medicine. 130 p.
Research output: Thesis › Doctoral Thesis (compilation)

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Cite this

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AU - Engedal, Knut

AU - Aarsland, Dag

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AU - Minthon, Lennart

AU - Londos, Elisabet

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KW - Randomized controlled trial

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Quality of Life and the Effect of Memantine in Dementia with Lewy Bodies and Parkinson's Disease Dementia.

Abstract

Subject classification (UKÄ)

Free keywords

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Research output

Living with Lewy body dementia. Treatment, survival & quality of life.

Cite this