TY - JOUR
T1 - Quantification of myocardial salvage by myocardial perfusion SPECT and cardiac magnetic resonance - reference standards for ECG development.
AU - Engblom, Henrik
AU - Aletras, Anthony
AU - Heiberg, Einar
AU - Arheden, Håkan
AU - Carlsson, Marcus
PY - 2014
Y1 - 2014
N2 - In order to determine the cardioprotective efficacy of acute reperfusion therapy, assessed as myocardial salvage, in patients with acute coronary occlusion, the final myocardial infarct (MI) size needs to be related to the amount of ischemic myocardium during coronary occlusion, referred to as the myocardium at risk (MaR). There are currently several imaging approaches available for quantification of both MI size and MaR in vivo of which some have been validated both in pre-clinical and clinical settings. These methods often involve the use of either myocardial perfusion SPECT or cardiac magnetic resonance (CMR). These imaging methods could potentially be used to further develop and validate ECG methods for determination of MI size and MaR. Therefore, the aim of the present review is to give an overview of myocardial perfusion SPECT and CMR methods available for assessment of myocardial salvage by determination of MI size and MaR.
AB - In order to determine the cardioprotective efficacy of acute reperfusion therapy, assessed as myocardial salvage, in patients with acute coronary occlusion, the final myocardial infarct (MI) size needs to be related to the amount of ischemic myocardium during coronary occlusion, referred to as the myocardium at risk (MaR). There are currently several imaging approaches available for quantification of both MI size and MaR in vivo of which some have been validated both in pre-clinical and clinical settings. These methods often involve the use of either myocardial perfusion SPECT or cardiac magnetic resonance (CMR). These imaging methods could potentially be used to further develop and validate ECG methods for determination of MI size and MaR. Therefore, the aim of the present review is to give an overview of myocardial perfusion SPECT and CMR methods available for assessment of myocardial salvage by determination of MI size and MaR.
U2 - 10.1016/j.jelectrocard.2014.04.001
DO - 10.1016/j.jelectrocard.2014.04.001
M3 - Review article
C2 - 24866753
SN - 1532-8430
VL - 47
SP - 525
EP - 534
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
IS - 4
ER -