Quantification of normal cerebral oxygen extraction and oxygen metabolism by phase-based MRI susceptometry: evaluation of repeatability using two different imaging protocols.

Robin Kämpe; Emelie Lind; Freddy Ståhlberg; Danielle van Westen; Linda Knutsson; Ronnie Wirestam

doi:10.1111/cpf.12288

Quantification of normal cerebral oxygen extraction and oxygen metabolism by phase-based MRI susceptometry: evaluation of repeatability using two different imaging protocols.

Robin Kämpe, Emelie Lind, Freddy Ståhlberg, Danielle van Westen, Linda Knutsson, Ronnie Wirestam

Skåne University Hospital

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Abstract

Global oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2 ) were quantified in a test-retest study. Cerebral blood flow (CBF) data, required for CMRO2 estimation, were obtained using dynamic susceptibility contrast MRI (DSC-MRI). OEF and CMRO2 were quantified using two separate data sets, that is, conventional high-resolution (HR) gradient echo (GRE) phase maps as well as echo planar imaging (EPI) phase maps taken from the baseline (precontrast) part of the DSC-MRI time series. The EPI phase data were included to elucidate whether an extra HR-GRE scan is needed to obtain information about OEF and CMRO2 , or if this information can be extracted from the DSC-MRI experiment only.

Original language	English
Pages (from-to)	2011-220
Journal	Clinical Physiology and Functional Imaging
Volume	37
Issue number	2
Early online date	2015 Oct 22
DOIs	https://doi.org/10.1111/cpf.12288
Publication status	Published - 2017

Subject classification (UKÄ)

Radiology, Nuclear Medicine and Medical Imaging
Other Physics Topics

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10.1111/cpf.12288

5210529 Accepted author manuscript, 1.36 MB

http://www.ncbi.nlm.nih.gov/pubmed/26490359?dopt=Abstract

Cite this

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title = "Quantification of normal cerebral oxygen extraction and oxygen metabolism by phase-based MRI susceptometry: evaluation of repeatability using two different imaging protocols.",

abstract = "Global oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2 ) were quantified in a test-retest study. Cerebral blood flow (CBF) data, required for CMRO2 estimation, were obtained using dynamic susceptibility contrast MRI (DSC-MRI). OEF and CMRO2 were quantified using two separate data sets, that is, conventional high-resolution (HR) gradient echo (GRE) phase maps as well as echo planar imaging (EPI) phase maps taken from the baseline (precontrast) part of the DSC-MRI time series. The EPI phase data were included to elucidate whether an extra HR-GRE scan is needed to obtain information about OEF and CMRO2 , or if this information can be extracted from the DSC-MRI experiment only.",

author = "Robin K{\"a}mpe and Emelie Lind and Freddy St{\aa}hlberg and {van Westen}, Danielle and Linda Knutsson and Ronnie Wirestam",

year = "2017",

doi = "10.1111/cpf.12288",

language = "English",

volume = "37",

pages = "2011--220",

journal = "Clinical Physiology and Functional Imaging",

issn = "1475-0961",

publisher = "John Wiley & Sons Inc.",

number = "2",

}

Quantification of normal cerebral oxygen extraction and oxygen metabolism by phase-based MRI susceptometry: evaluation of repeatability using two different imaging protocols. / Kämpe, Robin; Lind, Emelie ; Ståhlberg, Freddy et al.
In: Clinical Physiology and Functional Imaging, Vol. 37, No. 2, 2017, p. 2011-220.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Quantification of normal cerebral oxygen extraction and oxygen metabolism by phase-based MRI susceptometry: evaluation of repeatability using two different imaging protocols.

AU - Kämpe, Robin

AU - Lind, Emelie

AU - Ståhlberg, Freddy

AU - van Westen, Danielle

AU - Knutsson, Linda

AU - Wirestam, Ronnie

PY - 2017

Y1 - 2017

N2 - Global oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2 ) were quantified in a test-retest study. Cerebral blood flow (CBF) data, required for CMRO2 estimation, were obtained using dynamic susceptibility contrast MRI (DSC-MRI). OEF and CMRO2 were quantified using two separate data sets, that is, conventional high-resolution (HR) gradient echo (GRE) phase maps as well as echo planar imaging (EPI) phase maps taken from the baseline (precontrast) part of the DSC-MRI time series. The EPI phase data were included to elucidate whether an extra HR-GRE scan is needed to obtain information about OEF and CMRO2 , or if this information can be extracted from the DSC-MRI experiment only.

AB - Global oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2 ) were quantified in a test-retest study. Cerebral blood flow (CBF) data, required for CMRO2 estimation, were obtained using dynamic susceptibility contrast MRI (DSC-MRI). OEF and CMRO2 were quantified using two separate data sets, that is, conventional high-resolution (HR) gradient echo (GRE) phase maps as well as echo planar imaging (EPI) phase maps taken from the baseline (precontrast) part of the DSC-MRI time series. The EPI phase data were included to elucidate whether an extra HR-GRE scan is needed to obtain information about OEF and CMRO2 , or if this information can be extracted from the DSC-MRI experiment only.

U2 - 10.1111/cpf.12288

DO - 10.1111/cpf.12288

M3 - Article

C2 - 26490359

SN - 1475-0961

VL - 37

SP - 2011

EP - 2220

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

IS - 2

ER -

Quantification of normal cerebral oxygen extraction and oxygen metabolism by phase-based MRI susceptometry: evaluation of repeatability using two different imaging protocols.

Abstract

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