Quantification of pulmonary pathology in cystic fibrosis-comparison between digital chest tomosynthesis and computed tomography

C. Meltzer; M. Gilljam; J. Vikgren; R. R. Norrlund; K. Vult Von Steyern; M. Båth; A. Johnsson

doi:10.1093/rpd/ncab017

Quantification of pulmonary pathology in cystic fibrosis-comparison between digital chest tomosynthesis and computed tomography

C. Meltzer, M. Gilljam, J. Vikgren, R. R. Norrlund, K. Vult Von Steyern, M. Båth, A. Johnsson

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF). Methods: DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Extent of disease was quantified according to modality-specific scoring systems. Statistical analysis included Spearman's rank correlation coefficient (r) and Krippendorff's alpha (α). Major findings: The median effective dose was 0.14 for DTS and 2.68 for CT. Intermodality correlation was very strong for total score and the subscores regarding bronchiectasis and bronchial wall-thickening (r = 0.82-0.91, P < 0.01). Interobserver reliability was high for total score, bronchiectasis and mucus plugging (α = 0.83-0.93) in DTS. Conclusion: Chest tomosynthesis could be a low-dose alternative to CT in quantitative estimation of structural lung disease in CF.

Original language	English
Pages (from-to)	434-442
Number of pages	9
Journal	Radiation Protection Dosimetry
Volume	195
Issue number	3-4
DOIs	https://doi.org/10.1093/rpd/ncab017
Publication status	Published - 2021 Oct 1
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Author(s) 2021 Published by Oxford University Press.

Subject classification (UKÄ)

Radiology, Nuclear Medicine and Medical Imaging

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10.1093/rpd/ncab017Licence: CC BY

Cite this

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title = "Quantification of pulmonary pathology in cystic fibrosis-comparison between digital chest tomosynthesis and computed tomography",

abstract = "Purpose: Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF). Methods: DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Extent of disease was quantified according to modality-specific scoring systems. Statistical analysis included Spearman's rank correlation coefficient (r) and Krippendorff's alpha (α). Major findings: The median effective dose was 0.14 for DTS and 2.68 for CT. Intermodality correlation was very strong for total score and the subscores regarding bronchiectasis and bronchial wall-thickening (r = 0.82-0.91, P < 0.01). Interobserver reliability was high for total score, bronchiectasis and mucus plugging (α = 0.83-0.93) in DTS. Conclusion: Chest tomosynthesis could be a low-dose alternative to CT in quantitative estimation of structural lung disease in CF.",

author = "C. Meltzer and M. Gilljam and J. Vikgren and Norrlund, {R. R.} and {Vult Von Steyern}, K. and M. B{\aa}th and A. Johnsson",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021 Published by Oxford University Press.",

year = "2021",

month = oct,

day = "1",

doi = "10.1093/rpd/ncab017",

language = "English",

volume = "195",

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T1 - Quantification of pulmonary pathology in cystic fibrosis-comparison between digital chest tomosynthesis and computed tomography

AU - Meltzer, C.

AU - Gilljam, M.

AU - Vikgren, J.

AU - Norrlund, R. R.

AU - Vult Von Steyern, K.

AU - Båth, M.

AU - Johnsson, A.

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Purpose: Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF). Methods: DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Extent of disease was quantified according to modality-specific scoring systems. Statistical analysis included Spearman's rank correlation coefficient (r) and Krippendorff's alpha (α). Major findings: The median effective dose was 0.14 for DTS and 2.68 for CT. Intermodality correlation was very strong for total score and the subscores regarding bronchiectasis and bronchial wall-thickening (r = 0.82-0.91, P < 0.01). Interobserver reliability was high for total score, bronchiectasis and mucus plugging (α = 0.83-0.93) in DTS. Conclusion: Chest tomosynthesis could be a low-dose alternative to CT in quantitative estimation of structural lung disease in CF.

AB - Purpose: Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF). Methods: DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Extent of disease was quantified according to modality-specific scoring systems. Statistical analysis included Spearman's rank correlation coefficient (r) and Krippendorff's alpha (α). Major findings: The median effective dose was 0.14 for DTS and 2.68 for CT. Intermodality correlation was very strong for total score and the subscores regarding bronchiectasis and bronchial wall-thickening (r = 0.82-0.91, P < 0.01). Interobserver reliability was high for total score, bronchiectasis and mucus plugging (α = 0.83-0.93) in DTS. Conclusion: Chest tomosynthesis could be a low-dose alternative to CT in quantitative estimation of structural lung disease in CF.

U2 - 10.1093/rpd/ncab017

DO - 10.1093/rpd/ncab017

M3 - Article

C2 - 33683309

AN - SCOPUS:85118597847

SN - 1742-3406

VL - 195

SP - 434

EP - 442

JO - Radiation Protection Dosimetry

JF - Radiation Protection Dosimetry

IS - 3-4

ER -

Quantification of pulmonary pathology in cystic fibrosis-comparison between digital chest tomosynthesis and computed tomography

Abstract

Bibliographical note

Subject classification (UKÄ)

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