TY - JOUR
T1 - Rangelia vitalii
T2 - changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs
AU - Costa, Márcio Machado
AU - França, Raqueli Teresinha
AU - Da Silva, Aleksandro Schafer
AU - Paim, Carlos Breno
AU - Paim, Francine
AU - do Amaral, Carlos Henrique
AU - Dornelles, Guilherme Lopes
AU - da Cunha, João Paulo Monteiro Carvalho Mori
AU - Soares, João Fabio
AU - Labruna, Marcelo Bahia
AU - Mazzanti, Cinthia Melazzo Andrade
AU - Monteiro, Silvia Gonzalez
AU - Lopes, Sonia Terezinha Dos Anjos
PY - 2012/10/17
Y1 - 2012/10/17
N2 - Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7). Blood samples were collected on days 0, 10, 20 and 30 after infection, using tubes without anticoagulant to obtain serum and analyze the biochemical parameters. An increase in alanine aminotransferase (ALT) on day 20 (P < 0.05) was observed. Also, increased creatine kinase (CK) and aspartate aminotransferase (AST) levels were observed throughout the experimental period (P < 0.05). No changes in the serum gamma-glutamyltransferase, urea and creatinine levels were observed. Thus, is possible to conclude that experimental infection with R. vitalii in dogs causes changes to the biochemical profile, with increased ALT, AST and CK enzyme levels.
AB - Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7). Blood samples were collected on days 0, 10, 20 and 30 after infection, using tubes without anticoagulant to obtain serum and analyze the biochemical parameters. An increase in alanine aminotransferase (ALT) on day 20 (P < 0.05) was observed. Also, increased creatine kinase (CK) and aspartate aminotransferase (AST) levels were observed throughout the experimental period (P < 0.05). No changes in the serum gamma-glutamyltransferase, urea and creatinine levels were observed. Thus, is possible to conclude that experimental infection with R. vitalii in dogs causes changes to the biochemical profile, with increased ALT, AST and CK enzyme levels.
KW - Acute Disease
KW - Alanine Transaminase/blood
KW - Animals
KW - Aspartate Aminotransferases/blood
KW - Creatine Kinase/blood
KW - Dog Diseases/blood
KW - Dogs
KW - Female
KW - Protozoan Infections, Animal/blood
U2 - 10.1590/S1984-29612012000300012
DO - 10.1590/S1984-29612012000300012
M3 - Article
C2 - 23070434
SN - 0103-846X
VL - 21
SP - 243
EP - 248
JO - Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria
JF - Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria
IS - 3
ER -