@inproceedings{8f6a520b2211422299c37b5d71a9f2e5,
title = "Rapid fabrication of PMMA/PET-E/PMMA for thermoplastic microfluidic membrane devices",
abstract = "We present a method to rapidly fabricate a large number of thermoplastic microfluidic systems where horizontal microchannels are separated by a porous membrane for modelling biological barriers. We optimize and combine solvent bonding, milling and laser cutting to fabricate in excess of 100 devices in two days. The optimized protocol relies on a commercial solvent blend, retention grooves for solvent distribution, and force application to create strong, leak-free bonds. The devices are evaluated for suitability for modelling biological barriers by culturing endothelial cells and measuring permeability using a plate reader.",
keywords = "Laser cutting, Milling, Organ-on-a-chip, PET, PMMA, Solvent bonding, Thermoplastics",
author = "Henrik Persson and Siwan Park and Michael Mohan and Edmond Young and Simmons, \{Craig A.\}",
year = "2019",
language = "English",
series = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",
publisher = "Chemical and Biological Microsystems Society",
pages = "1666--1667",
booktitle = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",
note = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 ; Conference date: 27-10-2019 Through 31-10-2019",
}