Receptors involved in the nervous system regulation of polyamine metabolism in rat salivary glands

J. Ekström; B Månsson; G Tobin; B O Nilsson; Elsa Rosengren

doi:10.1111/j.1748-1716.1989.tb08575.x

Receptors involved in the nervous system regulation of polyamine metabolism in rat salivary glands

J. Ekström, B Månsson, G Tobin, B O Nilsson, Elsa Rosengren

Malmö University

Research output: Contribution to journal › Article › peer-review

Abstract

Polyamines are important for protein synthesis and tissue growth. In rat salivary glands, the activity of ornithine decarboxylase (ODC), the enzyme catalysing the formation of putrescine, and the content of putrescine, spermidine, spermine and N1-acetylspermidine were assayed after parasympathetic or sympathetic nerve stimulation in the presence of various autonomic receptor blockers. Increases in ODC activity occurred on activation of non-adrenergic and non-cholinergic receptors in response to parasympathetic nerve stimulation and on activation of alpha(alpha 1)- as well as of beta(beta 1)-adrenoceptors in response to sympathetic nerve stimulation. Moreover, in parotid glands, a beta(beta 1)-adrenoceptor-mediated inverse pathway for putrescine formation seemed to exist: from spermidine via N1-acetylspermidine.

Original language	English
Pages (from-to)	255-61
Journal	Acta Physiologica Scandinavica
Volume	135
Issue number	3
DOIs	https://doi.org/10.1111/j.1748-1716.1989.tb08575.x
Publication status	Published - 1989 Mar

Free keywords

Animals
Atropine
Dihydroergotamine
Male
Ornithine Decarboxylase
Parasympathetic Nervous System
Phentolamine
Propranolol
Putrescine
Rats
Rats, Inbred Strains
Salivary Glands
Spermidine
Spermine
Sympathetic Nervous System
Yohimbine

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10.1111/j.1748-1716.1989.tb08575.x

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title = "Receptors involved in the nervous system regulation of polyamine metabolism in rat salivary glands",

abstract = "Polyamines are important for protein synthesis and tissue growth. In rat salivary glands, the activity of ornithine decarboxylase (ODC), the enzyme catalysing the formation of putrescine, and the content of putrescine, spermidine, spermine and N1-acetylspermidine were assayed after parasympathetic or sympathetic nerve stimulation in the presence of various autonomic receptor blockers. Increases in ODC activity occurred on activation of non-adrenergic and non-cholinergic receptors in response to parasympathetic nerve stimulation and on activation of alpha(alpha 1)- as well as of beta(beta 1)-adrenoceptors in response to sympathetic nerve stimulation. Moreover, in parotid glands, a beta(beta 1)-adrenoceptor-mediated inverse pathway for putrescine formation seemed to exist: from spermidine via N1-acetylspermidine.",

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author = "J. Ekstr{\"o}m and B M{\aa}nsson and G Tobin and Nilsson, {B O} and Elsa Rosengren",

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T1 - Receptors involved in the nervous system regulation of polyamine metabolism in rat salivary glands

AU - Ekström, J.

AU - Månsson, B

AU - Tobin, G

AU - Nilsson, B O

AU - Rosengren, Elsa

PY - 1989/3

Y1 - 1989/3

N2 - Polyamines are important for protein synthesis and tissue growth. In rat salivary glands, the activity of ornithine decarboxylase (ODC), the enzyme catalysing the formation of putrescine, and the content of putrescine, spermidine, spermine and N1-acetylspermidine were assayed after parasympathetic or sympathetic nerve stimulation in the presence of various autonomic receptor blockers. Increases in ODC activity occurred on activation of non-adrenergic and non-cholinergic receptors in response to parasympathetic nerve stimulation and on activation of alpha(alpha 1)- as well as of beta(beta 1)-adrenoceptors in response to sympathetic nerve stimulation. Moreover, in parotid glands, a beta(beta 1)-adrenoceptor-mediated inverse pathway for putrescine formation seemed to exist: from spermidine via N1-acetylspermidine.

AB - Polyamines are important for protein synthesis and tissue growth. In rat salivary glands, the activity of ornithine decarboxylase (ODC), the enzyme catalysing the formation of putrescine, and the content of putrescine, spermidine, spermine and N1-acetylspermidine were assayed after parasympathetic or sympathetic nerve stimulation in the presence of various autonomic receptor blockers. Increases in ODC activity occurred on activation of non-adrenergic and non-cholinergic receptors in response to parasympathetic nerve stimulation and on activation of alpha(alpha 1)- as well as of beta(beta 1)-adrenoceptors in response to sympathetic nerve stimulation. Moreover, in parotid glands, a beta(beta 1)-adrenoceptor-mediated inverse pathway for putrescine formation seemed to exist: from spermidine via N1-acetylspermidine.

KW - Animals

KW - Atropine

KW - Dihydroergotamine

KW - Male

KW - Ornithine Decarboxylase

KW - Parasympathetic Nervous System

KW - Phentolamine

KW - Propranolol

KW - Putrescine

KW - Rats

KW - Rats, Inbred Strains

KW - Salivary Glands

KW - Spermidine

KW - Spermine

KW - Sympathetic Nervous System

KW - Yohimbine

U2 - 10.1111/j.1748-1716.1989.tb08575.x

DO - 10.1111/j.1748-1716.1989.tb08575.x

M3 - Article

C2 - 2929365

SN - 0001-6772

VL - 135

SP - 255

EP - 261

JO - Acta Physiologica Scandinavica

JF - Acta Physiologica Scandinavica

IS - 3

ER -

Receptors involved in the nervous system regulation of polyamine metabolism in rat salivary glands

Abstract

Free keywords

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