Reference Region-Based Pharmacokinetic Modeling in Quantitative Dynamic Contract-Enhanced MRI Allows Robust Treatment Monitoring in a Rat Liver Tumor Model Despite Cardiovascular Changes

Andreas Steingoetter, Jonas Svensson, Yvonne Kosanke, Rene M. Botnar, Markus Schwaiger, Ernst Rummeny, Rickmer Braren

Research output: Contribution to journalArticlepeer-review

9 Citations (SciVal)

Abstract

In this work, two pharmacokinetic modeling techniques, population arterial input function model, and reference region model, were applied to dynamic contract-enhanced MRI data, to test the influence of a change in heart rate on modeling parameters. A rat population arterial input function was generated by dynamic contrast-enhanced computed tomography measurements using the MR contrast agent gadolinium diethylenetriamine penta-acetic acid. Then, dynamic contract-enhanced MRI was used for treatment monitoring in two groups of hepatocellular carcinoma bearing rats. Whereas group 1 had the same heart rate as animals analyzed for the population arterial input function (263 +/- 20 bpm), group 2 had a higher heart rate (369 +/- 11 bpm) due to a different anesthesia protocol. The pharmacokinetic modeling parameters volume transfer constant K-trans and relative extravascular extracellular space v(e) were calculated with both models and statistically compared. For group 1, good correlation and agreement was found between the models showing no difference in K-trans and v(e) (Delta K-trans:4 +/- 19% and Delta v(e):4 +/- 12%, P = 0.2). In contrast, for group 2, a bias in parameter values for the population arterial input function model was detected (Delta K-trans: -45 +/- 7% and Delta v(e):-31 +/- 7%, P <= 0.001). The presented work underlines the value of the reference region model in longitudinal treatment monitoring and provides a straightforward approach for the generation of a rat population arterial input function. Magn Reson Med 65: 229-238, 2011. (C) 2010 Wiley-Liss, Inc.
Original languageEnglish
Pages (from-to)229-238
JournalMagnetic Resonance in Medicine
Volume65
Issue number1
DOIs
Publication statusPublished - 2011

Subject classification (UKÄ)

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • quantitative dynamic contract-enhanced MRI
  • population arterial input
  • function
  • reference region model
  • hepatocellular carcinoma rat tumor
  • model

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