Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape

William W. Agace, Kathy D McCoy

Research output: Contribution to journalReview articlepeer-review

Abstract

The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.

Original languageEnglish
Pages (from-to)532-548
Number of pages17
JournalImmunity
Volume46
Issue number4
DOIs
Publication statusPublished - 2017 Apr 18

Subject classification (UKÄ)

  • Immunology in the medical area

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