Regulation of human neutrophil granule protein expression

N Borregaard, K Theilgaard-Monch, Ole E Sørensen, J B Cowland

Research output: Contribution to journalArticlepeer-review


The function of the mature polymorphonuclear neutrophil is dependent on its granules, each with its characteristic content of proteins. The granule proteins are formed at different stages during maturation of neutrophils from myeloblasts to segmented cells. The regulation of granule protein expression is controlled by a number of transcription factors, many of which are also essential for commitment of multipotent hematopoietic stem cells to lineage-committed myeloid progenitor cells and for differentiation of these progenitor cells; among these, PU.1 and C/EBPalpha stand out as critical for all granule proteins whereas AML-1 is critical for primary granule protein expression and C/EBPepsilon for secondary and tertiary granule protein expression.
Original languageEnglish
Pages (from-to)23-27
JournalCurrent Opinion in Hematology
Issue number1
Publication statusPublished - 2001

Subject classification (UKÄ)

  • Hematology


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