Regulation of ornithine decarboxylase expression

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

    1 Citation (SciVal)

    Abstract

    It has become increasingly obvious during the last two decades that a multitude of cellular processes are highly dependent on adequate levels of polyamines (1–6). Too high concentrations of the polyamines are toxic to the cell and may induce cell death or apoptosis (7). On the other hand, too low concentrations may negatively affect anabolic events, such as the synthesis of DNA, RNA, and protein, eventually giving rise to cellgrowth arrest (6). Thus it is important for cells to maintain their polyamine concentrations within rather narrow limits. Polyamine homeostasis is achieved by a careful balance between synthesis, degradation, and uptake of the amines (3). The introduction of molecular techniques in studies concerning polyamine metabolism has revealed a complex network of regulatory mechanisms involved in the cellular control of polyamine levels.
    Original languageEnglish
    Title of host publicationPolyamine Cell signaling: Physiology, Pharmacology, and Cancer Research
    EditorsJ-Y Wang, R A Casero
    PublisherHumana Press
    Pages399-414
    ISBN (Print)978-1-58829-625-2
    DOIs
    Publication statusPublished - 2006

    Subject classification (UKÄ)

    • Pharmacology and Toxicology

    Fingerprint

    Dive into the research topics of 'Regulation of ornithine decarboxylase expression'. Together they form a unique fingerprint.

    Cite this