Regulation of stroke-induced neurogenesis in adult brain--recent scientific progress.

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Abstract

Stroke induced by middle cerebral artery occlusion in adult rodents induces the formation of new neurons in the damaged striatum, a region that normally does not show neurogenesis. Here we describe recent findings on the regulation of neurogenesis after stroke, in particular regarding the duration of the neurogenic response and the influence of age, as well as the molecular mechanisms influencing migration and survival of the new neurons. We also discuss some crucial issues that need to be addressed in the further exploration of this potential self-repair mechanism after damage to the adult brain.
Original languageEnglish
Pages (from-to)i162-i167
JournalCerebral Cortex
Volume16
DOIs
Publication statusPublished - 2006
EventProgress in Corticogenesis - Santorini, Greece
Duration: 2005 May 122005 May 15

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Restorative Neurology (0131000160), Stem Cell Center (013041110), Neurology, Lund (013027000)

Subject classification (UKÄ)

  • Neurology

Keywords

  • striatum
  • stroke
  • neurogenesis
  • neural stem cells
  • migration
  • subventricular zone

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