Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia.

Anne-Sofie Grell; Rushani Thigarajah; Lars Edvinsson; Ajoy Kumar Samraj

doi:10.1371/journal.pone.0113624

Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia.

Anne-Sofie Grell, Rushani Thigarajah, Lars Edvinsson, Ajoy Kumar Samraj

Medicine/Emergency Medicine, Lund

Research output: Contribution to journal › Article › peer-review

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Abstract

Increased expression of endothelin receptor type B (ETBR), a vasoactive receptor, has recently been implied in the reduced cerebral blood flow and exacerbated neuronal damage after ischemia-reperfusion (I/R). The study explores the regulatory mechanisms of ETBR to identify drug targets to restore normal cerebral artery contractile function as part of successful neuroprotective therapy.

Original language	English
Article number	e113624
Journal	PLoS ONE
Volume	9
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0113624
Publication status	Published - 2014

Subject classification (UKÄ)

Other Clinical Medicine

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Plos_Grell_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25479176?dopt=Abstract

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title = "Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia.",

abstract = "Increased expression of endothelin receptor type B (ETBR), a vasoactive receptor, has recently been implied in the reduced cerebral blood flow and exacerbated neuronal damage after ischemia-reperfusion (I/R). The study explores the regulatory mechanisms of ETBR to identify drug targets to restore normal cerebral artery contractile function as part of successful neuroprotective therapy.",

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AB - Increased expression of endothelin receptor type B (ETBR), a vasoactive receptor, has recently been implied in the reduced cerebral blood flow and exacerbated neuronal damage after ischemia-reperfusion (I/R). The study explores the regulatory mechanisms of ETBR to identify drug targets to restore normal cerebral artery contractile function as part of successful neuroprotective therapy.

U2 - 10.1371/journal.pone.0113624

DO - 10.1371/journal.pone.0113624

M3 - Article

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JO - PLoS ONE

JF - PLoS ONE

IS - 12

M1 - e113624

ER -

Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia.

Abstract

Subject classification (UKÄ)

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