Reovirus type 1 associated with meningitis

Hugo Johansson; Tomas Sveger; Karin Ahlfors; Jarl Ekstrand; Lennart Svensson

doi:10.3109/00365549609049060

Reovirus type 1 associated with meningitis

Hugo Johansson, Tomas Sveger, Karin Ahlfors, Jarl Ekstrand, Lennart Svensson

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Abstract

A previously healthy 3-month-old girl presented with symptoms of meningitis, diarrhoea, vomiting and fever. Green monkey kidney (GMK) cells inoculated with cerebrospinal fluid (CSF) revealed reovirus-like particles by electron microscopy. RNA-gel electrophoresis, immunofluorescence and virus neutralization identified the pathogen isolated from CSF as reovirus type 1. Antibody determination by immunofluorescence of paired sera showed a significant antibody titre rise to the CSF isolate and neutralization test revealed a greater than 4-fold antibody titre rise to the CSF isolate. The CSF isolate was also neutralized by reovirus type 1 antibodies. This report represents one of a few associating reovirus with CNS symptoms in humans.

Original language	English
Pages (from-to)	117-120
Journal	Scandinavian Journal of Infectious Diseases
Volume	28
Issue number	2
DOIs	https://doi.org/10.3109/00365549609049060
Publication status	Published - 1996

Subject classification (UKÄ)

Infectious Medicine

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10.3109/00365549609049060

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title = "Reovirus type 1 associated with meningitis",

abstract = "A previously healthy 3-month-old girl presented with symptoms of meningitis, diarrhoea, vomiting and fever. Green monkey kidney (GMK) cells inoculated with cerebrospinal fluid (CSF) revealed reovirus-like particles by electron microscopy. RNA-gel electrophoresis, immunofluorescence and virus neutralization identified the pathogen isolated from CSF as reovirus type 1. Antibody determination by immunofluorescence of paired sera showed a significant antibody titre rise to the CSF isolate and neutralization test revealed a greater than 4-fold antibody titre rise to the CSF isolate. The CSF isolate was also neutralized by reovirus type 1 antibodies. This report represents one of a few associating reovirus with CNS symptoms in humans.",

author = "Hugo Johansson and Tomas Sveger and Karin Ahlfors and Jarl Ekstrand and Lennart Svensson",

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T1 - Reovirus type 1 associated with meningitis

AU - Johansson, Hugo

AU - Sveger, Tomas

AU - Ahlfors, Karin

AU - Ekstrand, Jarl

AU - Svensson, Lennart

PY - 1996

Y1 - 1996

N2 - A previously healthy 3-month-old girl presented with symptoms of meningitis, diarrhoea, vomiting and fever. Green monkey kidney (GMK) cells inoculated with cerebrospinal fluid (CSF) revealed reovirus-like particles by electron microscopy. RNA-gel electrophoresis, immunofluorescence and virus neutralization identified the pathogen isolated from CSF as reovirus type 1. Antibody determination by immunofluorescence of paired sera showed a significant antibody titre rise to the CSF isolate and neutralization test revealed a greater than 4-fold antibody titre rise to the CSF isolate. The CSF isolate was also neutralized by reovirus type 1 antibodies. This report represents one of a few associating reovirus with CNS symptoms in humans.

AB - A previously healthy 3-month-old girl presented with symptoms of meningitis, diarrhoea, vomiting and fever. Green monkey kidney (GMK) cells inoculated with cerebrospinal fluid (CSF) revealed reovirus-like particles by electron microscopy. RNA-gel electrophoresis, immunofluorescence and virus neutralization identified the pathogen isolated from CSF as reovirus type 1. Antibody determination by immunofluorescence of paired sera showed a significant antibody titre rise to the CSF isolate and neutralization test revealed a greater than 4-fold antibody titre rise to the CSF isolate. The CSF isolate was also neutralized by reovirus type 1 antibodies. This report represents one of a few associating reovirus with CNS symptoms in humans.

U2 - 10.3109/00365549609049060

DO - 10.3109/00365549609049060

M3 - Article

VL - 28

SP - 117

EP - 120

JO - Infectious Diseases

JF - Infectious Diseases

SN - 2374-4235

IS - 2

ER -

Reovirus type 1 associated with meningitis

Abstract

Subject classification (UKÄ)

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