TY - JOUR
T1 - Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition
AU - Clasen, Joanna L.
AU - Mabunda, Rita
AU - Heath, Alicia K.
AU - Kaaks, Rudolf
AU - Katzke, Verena
AU - Schulze, Matthias B.
AU - Birukov, Anna
AU - Tagliabue, Giovanna
AU - Chiodini, Paolo
AU - Tumino, Rosario
AU - Milani, Lorenzo
AU - Braaten, Tonje
AU - Gram, Inger
AU - Lukic, Marko
AU - Luján-Barroso, Leila
AU - Rodriguez-Barranco, Miguel
AU - Chirlaque, María Dolores
AU - Ardanaz, Eva
AU - Amiano, Pilar
AU - Manjer, Jonas
AU - Huss, Linnea
AU - Ljungberg, Börje
AU - Travis, Ruth
AU - Smith-Byrne, Karl
AU - Gunter, Marc
AU - Johansson, Matthias
AU - Rinaldi, Sabina
AU - Weiderpass, Elisabete
AU - Riboli, Elio
AU - Cross, Amanda J.
AU - Muller, David C.
PY - 2023/7
Y1 - 2023/7
N2 - Background: Renal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology. Materials & Methods: We investigated associations of age at menarche and age at menopause, pregnancy-related factors, hysterectomy and ovariectomy and exogenous hormone use with RCC risk among 298,042 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Results: During 15 years of follow-up, 438 RCC cases were identified. Parous women had higher rates of RCC compared with nulliparous women (HR = 1.71, 95% CI 1.18, 2.46), and women who were older at age of first pregnancy had lower rates of RCC (30 years + vs. <20 years HR = 0.53, 95% CI 0.34, 0.82). Additionally, we identified a positive association for hysterectomy (HR = 1.43 95% CI 1.09, 1.86) and bilateral ovariectomy (HR = 1.67, 95% CI 1.13, 2.47), but not unilateral ovariectomy (HR = 0.99, 95% CI 0.61, 1.62) with RCC risk. No clear associations were found for age at menarche, age at menopause or exogenous hormone use. Conclusion: Our results suggest that parity and reproductive organ surgeries may play a role in RCC aetiology.
AB - Background: Renal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology. Materials & Methods: We investigated associations of age at menarche and age at menopause, pregnancy-related factors, hysterectomy and ovariectomy and exogenous hormone use with RCC risk among 298,042 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Results: During 15 years of follow-up, 438 RCC cases were identified. Parous women had higher rates of RCC compared with nulliparous women (HR = 1.71, 95% CI 1.18, 2.46), and women who were older at age of first pregnancy had lower rates of RCC (30 years + vs. <20 years HR = 0.53, 95% CI 0.34, 0.82). Additionally, we identified a positive association for hysterectomy (HR = 1.43 95% CI 1.09, 1.86) and bilateral ovariectomy (HR = 1.67, 95% CI 1.13, 2.47), but not unilateral ovariectomy (HR = 0.99, 95% CI 0.61, 1.62) with RCC risk. No clear associations were found for age at menarche, age at menopause or exogenous hormone use. Conclusion: Our results suggest that parity and reproductive organ surgeries may play a role in RCC aetiology.
U2 - 10.1002/cam4.6207
DO - 10.1002/cam4.6207
M3 - Article
C2 - 37269199
AN - SCOPUS:85161398621
SN - 2045-7634
VL - 12
SP - 15588
EP - 15600
JO - Cancer Medicine
JF - Cancer Medicine
IS - 14
ER -
