Reproductive Factors and Breast Cancer - Parity, Breastfeeding and Genetic Predisposition in Relation to Risk and Prognosis

Salma Butt

Reproductive Factors and Breast Cancer - Parity, Breastfeeding and Genetic Predisposition in Relation to Risk and Prognosis

Research output: Thesis › Doctoral Thesis (compilation)

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Abstract

The aim of this thesis was to study reproductive factors and genetic polymorphisms in relation to breast
cancer risk and survival. An important component of this was to investigate the risk of specific breast cancer
subgroups.
The association between parity and breast cancer-specific survival was studied among 4,453 women diagnosed
with breast cancer in Malmö, Sweden.
It was found that:
• Nulliparity and multiparity (≥4 children) were associated with a worse survival after breast cancer than
that of women with one child.
Parity, age at first childbirth and breastfeeding were examined in relation to the risk of specific breast
cancer subgroups among 17,035 women in The Malmö Diet and Cancer Study.
It was found that:
• Nulliparous women had a higher risk of more aggressive breast cancer subgroups than women with one
child.
• Women with a late first childbirth (>30 years) had a higher risk of more aggressive breast cancer subgroups
than women with an early first childbirth (≤20 years).
• Long duration of breastfeeding was associated with relatively aggressive breast cancer subgroups.
The potential interaction between parity/age at first childbirth and single nucleotide polymorphisms
(SNPs) was studied in The Malmö Diet and Cancer Study.
It was found that:
• Seven out of 14 investigated SNPs showed a statistically significant association with breast cancer risk.
Certain combinations of parity/age at first childbirth and SNPs might alter the susceptibility to breast
cancer.
We conclude that parity, breastfeeding and genetic predispostion are related to breast cancer risk and/or
prognosis.

Original language	English
Qualification	Doctor
Awarding Institution	Department of Clinical Sciences, Malmö
Supervisors/Advisors	Manjer, Jonas, Supervisor
Award date	2011 Feb 11
ISBN (Print)	978-91-86671-59-4
Publication status	Published - 2011

Bibliographical note

Defence details

Date: 2011-02-11
Time: 09:00
Place: Kvinnoklinikens aula, Ing 74, plan 3, SUS Malmö

External reviewer(s)

Name: Ekbom, Anders
Title: Prof
Affiliation: Institutionen för Medicin, Solna (MedS), Karolinska Universitetssjukhuset, 171 76 Stockholm

---

Subject classification (UKÄ)

Surgery
Clinical Medicine

Free keywords

subgroups
stage
survival
Breast cancer risk
parity
nulliparity
multiparity
breastfeeding
age at first birth
single nucleotide polymophisms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Salma_Butt_kappa

2 Article

Parity and age at first childbirth in relation to the risk of different breast cancer subgroups.
Butt, S., Borgquist, S., Anagnostaki, L., Landberg, G. & Manjer, J., 2009, In: International Journal of Cancer. 125, p. 1926-1934
Research output: Contribution to journal › Article › peer-review
Parity in relation to survival following breast cancer.
Butt, S., Borgquist, S., Garne, J. P., Landberg, G., Tengrup, I., Olsson, A. & Manjer, J., 2009, In: European Journal of Surgical Oncology. 35, p. 702-708
Research output: Contribution to journal › Article › peer-review

Cite this

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title = "Reproductive Factors and Breast Cancer - Parity, Breastfeeding and Genetic Predisposition in Relation to Risk and Prognosis",

abstract = "The aim of this thesis was to study reproductive factors and genetic polymorphisms in relation to breast cancer risk and survival. An important component of this was to investigate the risk of specific breast cancer subgroups. The association between parity and breast cancer-specific survival was studied among 4,453 women diagnosed with breast cancer in Malm{\"o}, Sweden. It was found that: • Nulliparity and multiparity (≥4 children) were associated with a worse survival after breast cancer than that of women with one child. Parity, age at first childbirth and breastfeeding were examined in relation to the risk of specific breast cancer subgroups among 17,035 women in The Malm{\"o} Diet and Cancer Study. It was found that: • Nulliparous women had a higher risk of more aggressive breast cancer subgroups than women with one child. • Women with a late first childbirth (>30 years) had a higher risk of more aggressive breast cancer subgroups than women with an early first childbirth (≤20 years). • Long duration of breastfeeding was associated with relatively aggressive breast cancer subgroups. The potential interaction between parity/age at first childbirth and single nucleotide polymorphisms (SNPs) was studied in The Malm{\"o} Diet and Cancer Study. It was found that: • Seven out of 14 investigated SNPs showed a statistically significant association with breast cancer risk. Certain combinations of parity/age at first childbirth and SNPs might alter the susceptibility to breast cancer. We conclude that parity, breastfeeding and genetic predispostion are related to breast cancer risk and/or prognosis.",

keywords = "subgroups, stage, survival, Breast cancer risk, parity, nulliparity, multiparity, breastfeeding, age at first birth, single nucleotide polymophisms",

author = "Salma Butt",

note = "Defence details Date: 2011-02-11 Time: 09:00 Place: Kvinnoklinikens aula, Ing 74, plan 3, SUS Malm{\"o} External reviewer(s) Name: Ekbom, Anders Title: Prof Affiliation: Institutionen f{\"o}r Medicin, Solna (MedS), Karolinska Universitetssjukhuset, 171 76 Stockholm ---",

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language = "English",

isbn = "978-91-86671-59-4",

series = "Lund University Faculty of Medicine Doctoral Dissertation Series ",

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T1 - Reproductive Factors and Breast Cancer - Parity, Breastfeeding and Genetic Predisposition in Relation to Risk and Prognosis

AU - Butt, Salma

N1 - Defence details Date: 2011-02-11 Time: 09:00 Place: Kvinnoklinikens aula, Ing 74, plan 3, SUS Malmö External reviewer(s) Name: Ekbom, Anders Title: Prof Affiliation: Institutionen för Medicin, Solna (MedS), Karolinska Universitetssjukhuset, 171 76 Stockholm ---

PY - 2011

Y1 - 2011

N2 - The aim of this thesis was to study reproductive factors and genetic polymorphisms in relation to breast cancer risk and survival. An important component of this was to investigate the risk of specific breast cancer subgroups. The association between parity and breast cancer-specific survival was studied among 4,453 women diagnosed with breast cancer in Malmö, Sweden. It was found that: • Nulliparity and multiparity (≥4 children) were associated with a worse survival after breast cancer than that of women with one child. Parity, age at first childbirth and breastfeeding were examined in relation to the risk of specific breast cancer subgroups among 17,035 women in The Malmö Diet and Cancer Study. It was found that: • Nulliparous women had a higher risk of more aggressive breast cancer subgroups than women with one child. • Women with a late first childbirth (>30 years) had a higher risk of more aggressive breast cancer subgroups than women with an early first childbirth (≤20 years). • Long duration of breastfeeding was associated with relatively aggressive breast cancer subgroups. The potential interaction between parity/age at first childbirth and single nucleotide polymorphisms (SNPs) was studied in The Malmö Diet and Cancer Study. It was found that: • Seven out of 14 investigated SNPs showed a statistically significant association with breast cancer risk. Certain combinations of parity/age at first childbirth and SNPs might alter the susceptibility to breast cancer. We conclude that parity, breastfeeding and genetic predispostion are related to breast cancer risk and/or prognosis.

AB - The aim of this thesis was to study reproductive factors and genetic polymorphisms in relation to breast cancer risk and survival. An important component of this was to investigate the risk of specific breast cancer subgroups. The association between parity and breast cancer-specific survival was studied among 4,453 women diagnosed with breast cancer in Malmö, Sweden. It was found that: • Nulliparity and multiparity (≥4 children) were associated with a worse survival after breast cancer than that of women with one child. Parity, age at first childbirth and breastfeeding were examined in relation to the risk of specific breast cancer subgroups among 17,035 women in The Malmö Diet and Cancer Study. It was found that: • Nulliparous women had a higher risk of more aggressive breast cancer subgroups than women with one child. • Women with a late first childbirth (>30 years) had a higher risk of more aggressive breast cancer subgroups than women with an early first childbirth (≤20 years). • Long duration of breastfeeding was associated with relatively aggressive breast cancer subgroups. The potential interaction between parity/age at first childbirth and single nucleotide polymorphisms (SNPs) was studied in The Malmö Diet and Cancer Study. It was found that: • Seven out of 14 investigated SNPs showed a statistically significant association with breast cancer risk. Certain combinations of parity/age at first childbirth and SNPs might alter the susceptibility to breast cancer. We conclude that parity, breastfeeding and genetic predispostion are related to breast cancer risk and/or prognosis.

KW - subgroups

KW - stage

KW - survival

KW - Breast cancer risk

KW - parity

KW - nulliparity

KW - multiparity

KW - breastfeeding

KW - age at first birth

KW - single nucleotide polymophisms

M3 - Doctoral Thesis (compilation)

SN - 978-91-86671-59-4

T3 - Lund University Faculty of Medicine Doctoral Dissertation Series

ER -

Reproductive Factors and Breast Cancer - Parity, Breastfeeding and Genetic Predisposition in Relation to Risk and Prognosis

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

UN SDGs

Access to Document

Fingerprint

Research output

Parity and age at first childbirth in relation to the risk of different breast cancer subgroups.

Parity in relation to survival following breast cancer.

Cite this