Research in motion: the enigma of Parkinson's disease pathology spread.

Patrik Brundin; Jia-Yi Li; Janice L Holton; Olle Lindvall; Tamas Revesz

doi:10.1038/nrn2477

Research in motion: the enigma of Parkinson's disease pathology spread.

Patrik Brundin, Jia-Yi Li, Janice L Holton, Olle Lindvall, Tamas Revesz

Research output: Contribution to journal › Review article › peer-review

Abstract

Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease.

Original language	English
Pages (from-to)	741-745
Journal	Nature Reviews Neuroscience
Volume	9
Issue number	10
DOIs	https://doi.org/10.1038/nrn2477
Publication status	Published - 2008

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neuronal Survival (013212041), Neurology, Lund (013027000), Neural Plasticity and Repair (013210080), Neurogenesis and cell therapy (013027500)

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Neurosciences

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10.1038/nrn2477

http://www.ncbi.nlm.nih.gov/pubmed/18769444?dopt=Abstract

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title = "Research in motion: the enigma of Parkinson's disease pathology spread.",

abstract = "Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease.",

author = "Patrik Brundin and Jia-Yi Li and Holton, {Janice L} and Olle Lindvall and Tamas Revesz",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Neurology, Lund (013027000), Neural Plasticity and Repair (013210080), Neurogenesis and cell therapy (013027500)",

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T1 - Research in motion: the enigma of Parkinson's disease pathology spread.

AU - Brundin, Patrik

AU - Li, Jia-Yi

AU - Holton, Janice L

AU - Lindvall, Olle

AU - Revesz, Tamas

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Neurology, Lund (013027000), Neural Plasticity and Repair (013210080), Neurogenesis and cell therapy (013027500)

PY - 2008

Y1 - 2008

N2 - Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease.

AB - Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease.

U2 - 10.1038/nrn2477

DO - 10.1038/nrn2477

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JO - Nature Reviews Neuroscience

JF - Nature Reviews Neuroscience

IS - 10

ER -

Research in motion: the enigma of Parkinson's disease pathology spread.

Abstract

Bibliographical note

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