Research in motion: the enigma of Parkinson's disease pathology spread.

Patrik Brundin, Jia-Yi Li, Janice L Holton, Olle Lindvall, Tamas Revesz

Research output: Contribution to journalReview articlepeer-review


Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease.
Original languageEnglish
Pages (from-to)741-745
JournalNature Reviews Neuroscience
Issue number10
Publication statusPublished - 2008

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neuronal Survival (013212041), Neurology, Lund (013027000), Neural Plasticity and Repair (013210080), Neurogenesis and cell therapy (013027500)

Subject classification (UKÄ)

  • Neurosciences


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