Resialylation of sialic acid deficit vascular endothelium, circulating cells and macromolecules may counteract the development of atherosclerosis: A hypothesis.

Gunnar Lindberg

    Research output: Contribution to journalArticlepeer-review

    15 Citations (SciVal)
    104 Downloads (Pure)

    Abstract

    Deficit sialylation of vascular endothelium, circulating cells and macromolecules has been associated with the development of atherosclerosis. On the other hand, an elevated serum level of sialic acid is a long-lasting marker of atherosclerosis and complications from atherosclerosis. One may speculate that the inverse associations with atherosclerosis risk are due to some common underlying cause. One mission for the elevated serum sialic acid level might be to act as a substrate for resialylation of sialic acid deficit structures and thereby counteract the atherosclerotic process.
    Original languageEnglish
    Pages (from-to)243-245
    JournalAtherosclerosis
    Volume192
    Issue number2
    DOIs
    Publication statusPublished - 2007

    Subject classification (UKÄ)

    • Cardiac and Cardiovascular Systems

    Keywords

    • sialic acid
    • resialylation
    • atherosclerosis
    • hypothesis

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