Respiratory Modulation in Permanent Atrial Fibrillation

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Several studies have shown that the autonomic nervous system (ANS) can induce changes during atrial fibrillation (AF). There is currently a lack of methods for quantifying ANS induced variations during AF. The purpose of this study is to quantify respiratory induced modulation in the f-wave frequency trend. Following qrst-cancellation, the local f-wave frequency is estimated by fitting a harmonic f-wave model signal and a quality index (SQI) is computed based on the model fit. The resulting frequency trend is filtered using a narrow bandpass filter with a center frequency corresponding to the local respiration rate. The magnitude of the respiratory induced f-wave frequency modulation is estimated by the envelope of the filtered frequency trend. The performance of the method is validated using simulations and the method is applied to analyze ECG data from eight patients with permanent AF recorded during 0.125 Hz frequency controlled respiration before and after the full vagal blockade, respectively. Results from simulated data show the magnitude of the respiratory induced f-wave frequency modulation can be estimated with an error of less than = 0.005Hz if the SQI is above 0.45. The signal quality was sufficient for analysis in 7 out of 8 patients. In 4 patients the magnitude decreased and in 3 patients there was no change.

Original languageEnglish
Title of host publication2020 Computing in Cardiology, CinC 2020
PublisherIEEE Computer Society
ISBN (Electronic)9781728173825
Publication statusPublished - 2020
Event2020 Computing in Cardiology, CinC 2020 - Rimini, Italy
Duration: 2020 Sep 132020 Sep 16

Publication series

NameComputing in Cardiology
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X


Conference2020 Computing in Cardiology, CinC 2020

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems


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