Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia

M. P.M. Boks; T. Rietkerk; M. H. van de Beek; I. E. Sommer; T. J. de Koning; R. S. Kahn

doi:10.1016/j.euroneuro.2006.12.003

Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia

M. P.M. Boks, T. Rietkerk, M. H. van de Beek, I. E. Sommer, T. J. de Koning, R. S. Kahn

University Medical Center Utrecht

Research output: Contribution to journal › Review article › peer-review

Abstract

We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in patients. The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia.

Original language	English
Pages (from-to)	567-572
Number of pages	6
Journal	European Neuropsychopharmacology
Volume	17
Issue number	9
DOIs	https://doi.org/10.1016/j.euroneuro.2006.12.003
Publication status	Published - 2007 Sept 1
Externally published	Yes

Subject classification (UKÄ)

Other Clinical Medicine

Free keywords

D-Serine
DAAO;
G72;
Glutamate;
Schizophrenia;

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10.1016/j.euroneuro.2006.12.003

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title = "Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia",

abstract = "We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in patients. The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia.",

keywords = "D-Serine, DAAO;, G72;, Glutamate;, Schizophrenia;",

author = "Boks, {M. P.M.} and T. Rietkerk and {van de Beek}, {M. H.} and Sommer, {I. E.} and {de Koning}, {T. J.} and Kahn, {R. S.}",

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AU - Boks, M. P.M.

AU - Rietkerk, T.

AU - van de Beek, M. H.

AU - Sommer, I. E.

AU - de Koning, T. J.

AU - Kahn, R. S.

PY - 2007/9/1

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N2 - We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in patients. The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia.

AB - We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in patients. The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia.

KW - D-Serine

KW - DAAO;

KW - G72;

KW - Glutamate;

KW - Schizophrenia;

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SN - 0924-977X

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SP - 567

EP - 572

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 9

ER -

Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia

Abstract

Subject classification (UKÄ)

Free keywords

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