RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.

Suchi Goel; Mia Palmkvist; Kirsten Moll; Nicolas Joannin; Patricia Lara; Reetesh R Akhouri; Nasim Moradi; Karin Öjemalm; Mattias Westman; Davide Angeletti; Hanna Kjellin; Janne Lehtiö; Ola Blixt; Lars Ideström; Carl G Gahmberg; Jill Storry; Annika Hult; Martin L Olsson; Gunnar von Heijne; IngMarie Nilsson; Mats Wahlgren

doi:10.1038/nm.3812

RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.

Suchi Goel, Mia Palmkvist, Kirsten Moll, Nicolas Joannin, Patricia Lara, Reetesh R Akhouri, Nasim Moradi, Karin Öjemalm, Mattias Westman, Davide Angeletti, Hanna Kjellin, Janne Lehtiö, Ola Blixt, Lars Ideström, Carl G Gahmberg, Jill Storry, Annika Hult, Martin L Olsson, Gunnar von Heijne, IngMarie NilssonMats Wahlgren

Research output: Contribution to journal › Article › peer-review

Abstract

Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.

Original language	English
Pages (from-to)	314-317
Journal	Nature Medicine
Volume	21
Issue number	4
DOIs	https://doi.org/10.1038/nm.3812
Publication status	Published - 2015

Subject classification (UKÄ)

Hematology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nm.3812

http://www.ncbi.nlm.nih.gov/pubmed/25751816?dopt=Abstract

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Goel, S., Palmkvist, M., Moll, K., Joannin, N., Lara, P., R Akhouri, R., Moradi, N., Öjemalm, K., Westman, M., Angeletti, D., Kjellin, H., Lehtiö, J., Blixt, O., Ideström, L., Gahmberg, C. G., Storry, J., Hult, A., Olsson, M. L., von Heijne, G., ... Wahlgren, M. (2015). RIFINs are adhesins implicated in severe Plasmodium falciparum malaria. Nature Medicine, 21(4), 314-317. https://doi.org/10.1038/nm.3812

@article{63ededd1b81d44d48675d9e2109c1370,

title = "RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.",

abstract = "Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.",

author = "Suchi Goel and Mia Palmkvist and Kirsten Moll and Nicolas Joannin and Patricia Lara and {R Akhouri}, Reetesh and Nasim Moradi and Karin {\"O}jemalm and Mattias Westman and Davide Angeletti and Hanna Kjellin and Janne Lehti{\"o} and Ola Blixt and Lars Idestr{\"o}m and Gahmberg, {Carl G} and Jill Storry and Annika Hult and Olsson, {Martin L} and {von Heijne}, Gunnar and IngMarie Nilsson and Mats Wahlgren",

year = "2015",

doi = "10.1038/nm.3812",

language = "English",

volume = "21",

pages = "314--317",

journal = "Nature Medicine",

issn = "1546-170X",

publisher = "Nature Publishing Group",

number = "4",

}

Goel, S, Palmkvist, M, Moll, K, Joannin, N, Lara, P, R Akhouri, R, Moradi, N, Öjemalm, K, Westman, M, Angeletti, D, Kjellin, H, Lehtiö, J, Blixt, O, Ideström, L, Gahmberg, CG, Storry, J , Hult, A , Olsson, ML, von Heijne, G, Nilsson, I & Wahlgren, M 2015, 'RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.', Nature Medicine, vol. 21, no. 4, pp. 314-317. https://doi.org/10.1038/nm.3812

TY - JOUR

T1 - RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.

AU - Goel, Suchi

AU - Palmkvist, Mia

AU - Moll, Kirsten

AU - Joannin, Nicolas

AU - Lara, Patricia

AU - R Akhouri, Reetesh

AU - Moradi, Nasim

AU - Öjemalm, Karin

AU - Westman, Mattias

AU - Angeletti, Davide

AU - Kjellin, Hanna

AU - Lehtiö, Janne

AU - Blixt, Ola

AU - Ideström, Lars

AU - Gahmberg, Carl G

AU - Storry, Jill

AU - Hult, Annika

AU - Olsson, Martin L

AU - von Heijne, Gunnar

AU - Nilsson, IngMarie

AU - Wahlgren, Mats

PY - 2015

Y1 - 2015

N2 - Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.

AB - Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.

U2 - 10.1038/nm.3812

DO - 10.1038/nm.3812

M3 - Article

C2 - 25751816

SN - 1546-170X

VL - 21

SP - 314

EP - 317

JO - Nature Medicine

JF - Nature Medicine

IS - 4

ER -

RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.

Abstract

Subject classification (UKÄ)

UN SDGs

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