RIFM fragrance ingredient safety assessment dihydro-β-terpinyl acetate, CAS Registry Number 26252-11-9

A. M. Api; D. Belsito; D. Botelho; D. Browne; M. Bruze; G. A. Burton; J. Buschmann; M. L. Dagli; M. Date; W. Dekant; C. Deodhar; M. Francis; A. D. Fryer; K. Joshi; S. La Cava; A. Lapczynski; D. C. Liebler; D. O'Brien; R. Parakhia; A. Patel; T. M. Penning; G. Ritacco; J. Romine; D. Salvito; T. W. Schultz; I. G. Sipes; Y. Thakkar; E. H. Theophilus; A. K. Tiethof; Y. Tokura; S. Tsang; J. Wahler

doi:10.1016/j.fct.2018.01.037

RIFM fragrance ingredient safety assessment dihydro-β-terpinyl acetate, CAS Registry Number 26252-11-9

A. M. Api, D. Belsito, D. Botelho, D. Browne, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, K. Joshi, S. La Cava, A. Lapczynski, D. C. Liebler, D. O'Brien, R. Parakhia, A. PatelT. M. Penning, G. Ritacco, J. Romine, D. Salvito, T. W. Schultz, I. G. Sipes, Y. Thakkar, E. H. Theophilus, A. K. Tiethof, Y. Tokura, S. Tsang, J. Wahler

Research output: Contribution to journal › Article › peer-review

Abstract

Summary: The use of this material under current conditions is supported by existing information. The material (dihydro-β-terpinyl acetate) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the read across analog menthyl acetate (1α,2β,5α) (CAS # 89-48-5) show that dihydro-β- terpinyl acetate is not genotoxic nor does it have skin sensitization potential. The repeated dose, reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on UV spectra. The environmental endpoints were evaluated, dihydro-β-terpinyl acetate was found not to be PBT as per the IFRA Environmental Standards and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC) are <1.

Original language	English
Pages (from-to)	S206-S213
Journal	Food and Chemical Toxicology
Volume	115
Early online date	2018 Feb 17
DOIs	https://doi.org/10.1016/j.fct.2018.01.037
Publication status	Published - 2018
Externally published	Yes

Subject classification (UKÄ)

Pharmacology and Toxicology

Free keywords

Environmental safety
Local respiratory toxicity
Phototoxicity/photoallergencity
Repeated dose, developmental and reproductive toxicity
Skin sensitization

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10.1016/j.fct.2018.01.037

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Api, A. M., Belsito, D., Botelho, D., Browne, D., Bruze, M., Burton, G. A., Buschmann, J., Dagli, M. L., Date, M., Dekant, W., Deodhar, C., Francis, M., Fryer, A. D., Joshi, K., La Cava, S., Lapczynski, A., Liebler, D. C., O'Brien, D., Parakhia, R., ... Wahler, J. (2018). RIFM fragrance ingredient safety assessment dihydro-β-terpinyl acetate, CAS Registry Number 26252-11-9. Food and Chemical Toxicology, 115, S206-S213. https://doi.org/10.1016/j.fct.2018.01.037

@article{69d2093f403c435db10742bf9e751b93,

title = "RIFM fragrance ingredient safety assessment dihydro-β-terpinyl acetate, CAS Registry Number 26252-11-9",

abstract = "Summary: The use of this material under current conditions is supported by existing information. The material (dihydro-β-terpinyl acetate) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the read across analog menthyl acetate (1α,2β,5α) (CAS # 89-48-5) show that dihydro-β- terpinyl acetate is not genotoxic nor does it have skin sensitization potential. The repeated dose, reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on UV spectra. The environmental endpoints were evaluated, dihydro-β-terpinyl acetate was found not to be PBT as per the IFRA Environmental Standards and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC) are <1.",

keywords = "Environmental safety, Local respiratory toxicity, Phototoxicity/photoallergencity, Repeated dose, developmental and reproductive toxicity, Skin sensitization",

author = "Api, {A. M.} and D. Belsito and D. Botelho and D. Browne and M. Bruze and Burton, {G. A.} and J. Buschmann and Dagli, {M. L.} and M. Date and W. Dekant and C. Deodhar and M. Francis and Fryer, {A. D.} and K. Joshi and {La Cava}, S. and A. Lapczynski and Liebler, {D. C.} and D. O'Brien and R. Parakhia and A. Patel and Penning, {T. M.} and G. Ritacco and J. Romine and D. Salvito and Schultz, {T. W.} and Sipes, {I. G.} and Y. Thakkar and Theophilus, {E. H.} and Tiethof, {A. K.} and Y. Tokura and S. Tsang and J. Wahler",

year = "2018",

doi = "10.1016/j.fct.2018.01.037",

language = "English",

volume = "115",

pages = "S206--S213",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

publisher = "Elsevier",

}

Api, AM, Belsito, D, Botelho, D, Browne, D, Bruze, M, Burton, GA, Buschmann, J, Dagli, ML, Date, M, Dekant, W, Deodhar, C, Francis, M, Fryer, AD, Joshi, K, La Cava, S, Lapczynski, A, Liebler, DC, O'Brien, D, Parakhia, R, Patel, A, Penning, TM, Ritacco, G, Romine, J, Salvito, D, Schultz, TW, Sipes, IG, Thakkar, Y, Theophilus, EH, Tiethof, AK, Tokura, Y, Tsang, S & Wahler, J 2018, 'RIFM fragrance ingredient safety assessment dihydro-β-terpinyl acetate, CAS Registry Number 26252-11-9', Food and Chemical Toxicology, vol. 115, pp. S206-S213. https://doi.org/10.1016/j.fct.2018.01.037

TY - JOUR

T1 - RIFM fragrance ingredient safety assessment dihydro-β-terpinyl acetate, CAS Registry Number 26252-11-9

AU - Api, A. M.

AU - Belsito, D.

AU - Botelho, D.

AU - Browne, D.

AU - Bruze, M.

AU - Burton, G. A.

AU - Buschmann, J.

AU - Dagli, M. L.

AU - Date, M.

AU - Dekant, W.

AU - Deodhar, C.

AU - Francis, M.

AU - Fryer, A. D.

AU - Joshi, K.

AU - La Cava, S.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - O'Brien, D.

AU - Parakhia, R.

AU - Patel, A.

AU - Penning, T. M.

AU - Ritacco, G.

AU - Romine, J.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Sipes, I. G.

AU - Thakkar, Y.

AU - Theophilus, E. H.

AU - Tiethof, A. K.

AU - Tokura, Y.

AU - Tsang, S.

AU - Wahler, J.

PY - 2018

Y1 - 2018

N2 - Summary: The use of this material under current conditions is supported by existing information. The material (dihydro-β-terpinyl acetate) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the read across analog menthyl acetate (1α,2β,5α) (CAS # 89-48-5) show that dihydro-β- terpinyl acetate is not genotoxic nor does it have skin sensitization potential. The repeated dose, reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on UV spectra. The environmental endpoints were evaluated, dihydro-β-terpinyl acetate was found not to be PBT as per the IFRA Environmental Standards and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC) are <1.

AB - Summary: The use of this material under current conditions is supported by existing information. The material (dihydro-β-terpinyl acetate) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the read across analog menthyl acetate (1α,2β,5α) (CAS # 89-48-5) show that dihydro-β- terpinyl acetate is not genotoxic nor does it have skin sensitization potential. The repeated dose, reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on UV spectra. The environmental endpoints were evaluated, dihydro-β-terpinyl acetate was found not to be PBT as per the IFRA Environmental Standards and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC) are <1.

KW - Environmental safety

KW - Local respiratory toxicity

KW - Phototoxicity/photoallergencity

KW - Repeated dose, developmental and reproductive toxicity

KW - Skin sensitization

U2 - 10.1016/j.fct.2018.01.037

DO - 10.1016/j.fct.2018.01.037

M3 - Article

C2 - 29408617

AN - SCOPUS:85042139485

SN - 0278-6915

VL - 115

SP - S206-S213

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

ER -

RIFM fragrance ingredient safety assessment dihydro-β-terpinyl acetate, CAS Registry Number 26252-11-9

Abstract

Subject classification (UKÄ)

Free keywords

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