TY - JOUR
T1 - RIFM fragrance ingredient safety assessment, ethyl 4-pentenoate, CAS Registry Number 1968-40-7
AU - Api, A. M.
AU - Belsito, D.
AU - Biserta, S.
AU - Botelho, D.
AU - Bruze, M.
AU - Burton, G. A.
AU - Buschmann, J.
AU - Cancellieri, M. A.
AU - Dagli, M. L.
AU - Date, M.
AU - Dekant, W.
AU - Deodhar, C.
AU - Fryer, A. D.
AU - Gadhia, S.
AU - Jones, L.
AU - Joshi, K.
AU - Kumar, M.
AU - Lapczynski, A.
AU - Lavelle, M.
AU - Lee, I.
AU - Liebler, D. C.
AU - Moustakas, H.
AU - Na, M.
AU - Penning, T. M.
AU - Ritacco, G.
AU - Romine, J.
AU - Sadekar, N.
AU - Schultz, T. W.
AU - Selechnik, D.
AU - Siddiqi, F.
AU - Sipes, I. G.
AU - Sullivan, G.
AU - Thakkar, Y.
AU - Tokura, Y.
PY - 2021
Y1 - 2021
N2 - The existing information supports the use of this material as described in this safety assessment.Ethyl
4-pentenoate was evaluated for genotoxicity, repeated dose toxicity,
reproductive toxicity, local respiratory toxicity,
phototoxicity/photoallergenicity, skin sensitization, and environmental
safety. Data from read-across analog methyl undec-10-enoate (CAS #
111-81-9) show that ethyl 4-pentenoate is not expected to be genotoxic.
The repeated dose, reproductive, and local respiratory toxicity
endpoints were evaluated using the threshold of toxicological concern
(TTC) for a Cramer Class I material, and the exposure to ethyl
4-pentenoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and
1.4 mg/day, respectively). The skin sensitization endpoint was completed
using the dermal sensitization threshold (DST) for non-reactive
materials (900 μg/cm2); exposure is below the DST. The
phototoxicity/photoallergenicity endpoints were evaluated based on
ultraviolet (UV) spectra; ethyl 4-pentenoate is not expected to be
phototoxic/photoallergenic. The environmental endpoints were evaluated;
ethyl 4-pentenoate was found not to be persistent, bioaccumulative, and
toxic (PBT) as per the International Fragrance Association (IFRA)
Environmental Standards, and its risk quotients, based on its current
volume of use in Europe and North America (i.e., Predicted Environmental
Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
AB - The existing information supports the use of this material as described in this safety assessment.Ethyl
4-pentenoate was evaluated for genotoxicity, repeated dose toxicity,
reproductive toxicity, local respiratory toxicity,
phototoxicity/photoallergenicity, skin sensitization, and environmental
safety. Data from read-across analog methyl undec-10-enoate (CAS #
111-81-9) show that ethyl 4-pentenoate is not expected to be genotoxic.
The repeated dose, reproductive, and local respiratory toxicity
endpoints were evaluated using the threshold of toxicological concern
(TTC) for a Cramer Class I material, and the exposure to ethyl
4-pentenoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and
1.4 mg/day, respectively). The skin sensitization endpoint was completed
using the dermal sensitization threshold (DST) for non-reactive
materials (900 μg/cm2); exposure is below the DST. The
phototoxicity/photoallergenicity endpoints were evaluated based on
ultraviolet (UV) spectra; ethyl 4-pentenoate is not expected to be
phototoxic/photoallergenic. The environmental endpoints were evaluated;
ethyl 4-pentenoate was found not to be persistent, bioaccumulative, and
toxic (PBT) as per the International Fragrance Association (IFRA)
Environmental Standards, and its risk quotients, based on its current
volume of use in Europe and North America (i.e., Predicted Environmental
Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
U2 - 10.1016/j.fct.2021.112048
DO - 10.1016/j.fct.2021.112048
M3 - Article
C2 - 33571608
AN - SCOPUS:85100807981
SN - 0278-6915
VL - 149
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
M1 - 112048
ER -