RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7.

A M Api; D Belsito; S Bhatia; Magnus Bruze; P Calow; M L Dagli; W Dekant; A D Fryer; L Kromidas; S La Cava; J F Lalko; A Lapczynski; D C Liebler; Y Miyachi; V T Politano; G Ritacco; D Salvito; T W Schultz; J Shen; I G Sipes; B Wall; D K Wilcox

doi:10.1016/j.fct.2015.09.014

RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7.

A M Api, D Belsito, S Bhatia, Magnus Bruze, P Calow, M L Dagli, W Dekant, A D Fryer, L Kromidas, S La Cava, J F Lalko, A Lapczynski, D C Liebler, Y Miyachi, V T Politano, G Ritacco, D Salvito, T W Schultz, J Shen, I G SipesB Wall, D K Wilcox

Skåne University Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using to have the most conservative systemic exposure derived NOAEL of 47 mg/kg/day. A dietary 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 2350 while considering 10.3% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

Original language	English
Journal	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Early online date	2015 Sept 28
DOIs	https://doi.org/10.1016/j.fct.2015.09.014
Publication status	Published - 2015
Externally published	Yes

Subject classification (UKÄ)

Environmental Health and Occupational Health

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10.1016/j.fct.2015.09.014

http://www.ncbi.nlm.nih.gov/pubmed/26419451?dopt=Abstract

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Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lalko, J. F., Lapczynski, A., Liebler, D. C., Miyachi, Y., Politano, V. T., Ritacco, G., Salvito, D., Schultz, T. W., Shen, J., ... Wilcox, D. K. (2015). RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. https://doi.org/10.1016/j.fct.2015.09.014

@article{77f86c6a49ce4afabe214b8c34ccdf65,

title = "RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7.",

abstract = "The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using to have the most conservative systemic exposure derived NOAEL of 47 mg/kg/day. A dietary 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 2350 while considering 10.3% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.",

author = "Api, {A M} and D Belsito and S Bhatia and Magnus Bruze and P Calow and Dagli, {M L} and W Dekant and Fryer, {A D} and L Kromidas and {La Cava}, S and Lalko, {J F} and A Lapczynski and Liebler, {D C} and Y Miyachi and Politano, {V T} and G Ritacco and D Salvito and Schultz, {T W} and J Shen and Sipes, {I G} and B Wall and Wilcox, {D K}",

year = "2015",

doi = "10.1016/j.fct.2015.09.014",

language = "English",

journal = "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association",

issn = "1873-6351",

publisher = "Elsevier",

}

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Miyachi, Y, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2015, 'RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7.', Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. https://doi.org/10.1016/j.fct.2015.09.014

TY - JOUR

T1 - RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7.

AU - Api, A M

AU - Belsito, D

AU - Bhatia, S

AU - Bruze, Magnus

AU - Calow, P

AU - Dagli, M L

AU - Dekant, W

AU - Fryer, A D

AU - Kromidas, L

AU - La Cava, S

AU - Lalko, J F

AU - Lapczynski, A

AU - Liebler, D C

AU - Miyachi, Y

AU - Politano, V T

AU - Ritacco, G

AU - Salvito, D

AU - Schultz, T W

AU - Shen, J

AU - Sipes, I G

AU - Wall, B

AU - Wilcox, D K

PY - 2015

Y1 - 2015

N2 - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using to have the most conservative systemic exposure derived NOAEL of 47 mg/kg/day. A dietary 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 2350 while considering 10.3% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

AB - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using to have the most conservative systemic exposure derived NOAEL of 47 mg/kg/day. A dietary 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 2350 while considering 10.3% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

U2 - 10.1016/j.fct.2015.09.014

DO - 10.1016/j.fct.2015.09.014

M3 - Article

C2 - 26419451

SN - 1873-6351

JO - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

ER -

RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7.

Abstract

Subject classification (UKÄ)

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