Risk factors for depressive disorders in the Lundby cohort - A 50 year prospective clinical follow-up.

Cecilia Mattisson, Mats Bogren, Vibeke Horstmann, Kristian Tambs, Povl Munk-Jörgensen, Per Nettelbladt

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BACKGROUND: Depressive disorders are common and disabling. The Lundby Study is a prospective study of a community sample that started in 1947(N=2550). In 1957, 1013 newcomers were added. The latest field investigation was carried out in 1997. AIM: To identify risk factors for depressive disorders. METHOD: The Lundby database contains clinical assessments of the subjects made by psychiatrists. It also includes information about socio-demographic factors and episodes of somatic and mental disorders. Two different but partly overlapping cohorts from the same geographical area in 1947 (N=2470) and in 1957 (N=3310) were investigated. During follow-up 418 individuals experienced their first depressive disorder. For each cohort, possible risk factors were analysed by means of Cox regression analyses for the whole sample and for each sex separately. CONCLUSION: The personality trait nervous/tense and anxiety disorders were statistically significant risk factors for depression for both genders. For males, the diagnoses alcohol disorders and tiredness disorder were risk factors. The personality trait subvalidity (low grade of energy) and nervous symptoms as a child were also risk factors for males. For females personality traits such as being easily hurt, abnormal/antisocial and tired/distracted were associated with depressive disorders. CLINICAL RELEVANCE: Knowledge of risk factors may help to reduce incidence of depression.
Original languageEnglish
Pages (from-to)203-215
JournalJournal of Affective Disorders
Issue number3
Publication statusPublished - 2009

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Psychiatry (Lund) (013303000), Division of Occupational Therapy (Closed 2012) (013025000)

Subject classification (UKÄ)

  • Psychiatry


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