RNA and metabolic disorders

Gaurav Verma, Susana González-Rico

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review


Obesity is reaching levels never seen before in the world population, causing a rise in the incidence of metabolic disorders. The increase of visceral storage of adipose tissue is related to chronic inflammation and deregulation of the metabolism, causing insulin resistance, dyslipidemia and endothelial dysfunction. These pathologies, when they appear together, are known as metabolic syndrome and are associated with an increased risk of atherosclerotic cardiovascular disease, and type 2 Diabetes Mellitus. Recent studies have demonstrated a close link between maternal nutrition and chronic metabolic disease, suggesting epigenetic mechanisms that could affect the way we face this problem in the future. In such context, is of great importance to fully understand the mechanisms that control expression of the genes involved. In this work we will focus on the role of RNA as a key regulatory element in the control of gene expression in metabolic disorders.

Original languageEnglish
Title of host publicationRNA-Based Regulation in Human Health and Disease
PublisherScienceDirect, Elsevier
Number of pages25
ISBN (Electronic)9780128171936
Publication statusPublished - 2020

Subject classification (UKÄ)

  • Endocrinology and Diabetes


  • Adipogenesis
  • Epigenetics
  • Gene regulation
  • LncRNA
  • Metabolic syndrome
  • MiRNA
  • PiRNA
  • RNA
  • SiRNA
  • Transcriptional control


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