TY - JOUR
T1 - Role of Helicobacter pylori in conjunctival mucosa-associated lymphoid tissue lymphoma
AU - Sjo, Nicolai C.
AU - Foegh, Pia
AU - Juhl, Birgitte R.
AU - Nilsson, Hans-Olof
AU - Prause, Jan U.
AU - Ralfkiaer, Elisabeth
AU - Wadström, Torkel
AU - Heegaard, Steffen
PY - 2007
Y1 - 2007
N2 - Objective: Conjunctiva-associated lymphoid tissue is the conjunctival equivalent to mucosa-associated lymphoid tissue (MALT). Mucosa-associated lymphoid tissue lymphoma has been shown to be associated with Helicobacter pylori. In this study, the prevalence and possible role of H. pylori infection in conjunctival MALT lymphoma were evaluated. Design: Retrospective noncomparative case series. Participants: Thirteen cases of conjunctival MALT lymphoma were investigated. Five samples of conjunctival lymphoid hyperplasia and 20 biopsies of normal conjunctiva served as controls. Methods: The specimens were investigated for the presence of H. pylori with immunohistochemistry (IHC) and nested polymerase chain reaction (PCR) techniques. For each case of conjunctival MALT lymphoma, information regarding gender, age at presentation, conjunctival localization, and information of generalized MALT lymphoma were collected. Main Outcome Measures: Detection of H. pylori and patient characteristics. Results: The 13 conjunctival MALT lymphomas originated from 8 women and 5 men with an average age of 62 years (range, 25-87). Only 1 patient had evidence of systemic MALT lymphoma. H. pylon could not be identified in any of the conjunctival MALT lymphomas, in conjunctival lymphoid hyperplasia, or in normal conjunctival biopsies using IHC and PCR techniques. Conclusions: An association between H. pylori and localized conjunctival MALT lymphoma could not be verified. Antigens other than H. pylon may take part in the development of conjunctival MALT lymphoma.
AB - Objective: Conjunctiva-associated lymphoid tissue is the conjunctival equivalent to mucosa-associated lymphoid tissue (MALT). Mucosa-associated lymphoid tissue lymphoma has been shown to be associated with Helicobacter pylori. In this study, the prevalence and possible role of H. pylori infection in conjunctival MALT lymphoma were evaluated. Design: Retrospective noncomparative case series. Participants: Thirteen cases of conjunctival MALT lymphoma were investigated. Five samples of conjunctival lymphoid hyperplasia and 20 biopsies of normal conjunctiva served as controls. Methods: The specimens were investigated for the presence of H. pylori with immunohistochemistry (IHC) and nested polymerase chain reaction (PCR) techniques. For each case of conjunctival MALT lymphoma, information regarding gender, age at presentation, conjunctival localization, and information of generalized MALT lymphoma were collected. Main Outcome Measures: Detection of H. pylori and patient characteristics. Results: The 13 conjunctival MALT lymphomas originated from 8 women and 5 men with an average age of 62 years (range, 25-87). Only 1 patient had evidence of systemic MALT lymphoma. H. pylon could not be identified in any of the conjunctival MALT lymphomas, in conjunctival lymphoid hyperplasia, or in normal conjunctival biopsies using IHC and PCR techniques. Conclusions: An association between H. pylori and localized conjunctival MALT lymphoma could not be verified. Antigens other than H. pylon may take part in the development of conjunctival MALT lymphoma.
U2 - 10.1016/j.ophtha.2006.09.020
DO - 10.1016/j.ophtha.2006.09.020
M3 - Article
SN - 1549-4713
VL - 114
SP - 182
EP - 186
JO - Ophthalmology
JF - Ophthalmology
IS - 1
ER -