RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design

Po-Ssu Huang, Yih-En Andrew Ban, Florian Richter, Ingemar André, Robert Vernon, William R. Schief, David Baker

Research output: Contribution to journalArticlepeer-review


We describe RosettaRemodel, a generalized framework for flexible protein design that provides a versatile and convenient interface to the Rosetta modeling suite. RosettaRemodel employs a unified interface, called a blueprint, which allows detailed control over many aspects of flexible backbone protein design calculations. RosettaRemodel allows the construction and elaboration of customized protocols for a wide range of design problems ranging from loop insertion and deletion, disulfide engineering, domain assembly, loop remodeling, motif grafting, symmetrical units, to de novo structure modeling.
Original languageEnglish
JournalPLoS ONE
Issue number8
Publication statusPublished - 2011

Subject classification (UKÄ)

  • Biological Sciences


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