Ru-Catalyzed Cross-Dehydrogenative Coupling between Primary Alcohols to Guerbet Alcohol Derivatives: With Relevance for Fragrance Synthesis

Seetharaman Manojveer, Saleh Salahi, Ola F. Wendt, Magnus T. Johnson

Research output: Contribution to journalArticlepeer-review

Abstract

A simple method has been developed for the cross dehydrogenative coupling between two different primary alcohols using readily available RuCl2(PPh3)3 as a precatalyst through the borrowing-hydrogen approach. The present methodology is applicable to a large variety of alcohol derivatives including long chain aliphatic alcohols and heteroaryl alcohols. In addition, the methodology was applied in a straightforward protocol to synthesize commercially available fragrances such as Rosaphen and Cyclamenaldehyde in good yields.

Original languageEnglish
Pages (from-to)10864-10870
Number of pages7
JournalJournal of Organic Chemistry
Volume83
Issue number18
DOIs
Publication statusPublished - 2018

Subject classification (UKÄ)

  • Organic Chemistry

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