S100A8/A9 is a valuable biomarker and treatment target to detect and modulate neutrophil involvement in myocardial infarction

Răzvan Gheorghiţă Mareş, Adrian Horaţiu Sabău, Iuliu Gabriel Cocuz, Mihaela Elena Tomuţ, Istvan Adorjan Szabo, Andreea Raluca Szőke, Andreea Cătălina Tinca, Gabriel Jakobsson, Ovidiu Simion Cotoi, Alexandru Şchiopu

Research output: Contribution to journalArticlepeer-review

Abstract

Myocardial infarction (MI) leads to irreversible ischemic damage of the heart muscle and is the leading cause of heart failure. The ischemic cardiac injury triggers a potent local and systemic immune response. In the acute phase post-MI, neutrophils infiltrate the myocardium in large numbers and induce further cardiomyocyte death, expanding the infarcted area. The alarmin S100A8/A9 is a proinflammatory mediator primarily produced by myeloid cells, with an emerging role in MI. We previously demonstrated that short-term inhibition of S100A8/A9 during the inflammatory phase of the immune response to MI improves long-term cardiac function. In the present study, we investigated the effects of S100A8/A9 blockade on myocardial inflammation and post-ischemic myocardial injury in a mouse model of coronary artery ligation. Immunohistochemical (IHC) staining revealed that the presence of S100A9 is strongly correlated with neutrophil infiltration in the myocardium on days 1 and 3 post-MI. A 3-day treatment with the S100A8/A9 blocker ABR-238901 starting immediately after MI decreased the number of neutrophils and S100A9 presence in the myocardium and had a positive impact on cardiac damage, reducing infarction size. These findings promote S100A9 as an IHC biomarker of neutrophil infiltration and a promising immunomodulatory target to regulate neutrophil recruitment, reduce ischemic injury and promote long-term beneficial cardiac recovery after MI.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalRomanian Journal of Morphology and Embryology
Volume64
Issue number2
DOIs
Publication statusPublished - 2023 Apr

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems

Free keywords

  • infarct size
  • inflammation
  • myocardial infarction
  • S100A8/A9 blockade

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