Saliva-Induced Clotting Captures Streptococci: Novel Roles for Coagulation and Fibrinolysis in Host Defense and Immune Evasion

Kristofer Wollein Waldetoft, Tirthankar Mohanty, Christofer Karlsson, Matthias Mörgelin, Inga-Maria Frick, Johan Malmström, Lars Björck

Research output: Contribution to journalArticlepeer-review

11 Citations (SciVal)

Abstract

Streptococcal pharyngitis is among the most common bacterial infections, but the molecular mechanisms involved remain poorly understood. Here we investigate the interactions among three major players in streptococcal pharyngitis: streptococci, plasma, and saliva. We find that saliva activates the plasma coagulation system through both the extrinsic and the intrinsic pathways, entrapping the bacteria in fibrin clots. The bacteria escape the clots by activating host plasminogen. Our results identify a potential function for the intrinsic pathway of coagulation in host defense and a corresponding role for fibrinolysis in streptococcal immune evasion.

Original languageEnglish
Pages (from-to)2813-23
Number of pages11
JournalInfection and Immunity
Volume84
Issue number10
DOIs
Publication statusPublished - 2016 Oct

Subject classification (UKÄ)

  • Infectious Medicine

Keywords

  • Journal Article

Fingerprint

Dive into the research topics of 'Saliva-Induced Clotting Captures Streptococci: Novel Roles for Coagulation and Fibrinolysis in Host Defense and Immune Evasion'. Together they form a unique fingerprint.

Cite this