Sarcomas associated with hereditary nonpolyposis colorectal cancer: broad anatomical and morphological spectrum

Mef Nilbert, Christina Therkildsen, Anja Nissen, Måns Åkerman, Inge Bernstein

Research output: Contribution to journalArticlepeer-review

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) is primarily linked to colorectal and endometrial cancer, but is associated with a broad tumor spectrum. Though not formally part of the syndrome, occasional sarcomas have been reported in individuals with HNPCC. We used the national Danish HNPCC-register to identify HNPCC families in which sarcomas had been diagnosed. Fourteen sarcomas were identified in families with mutations in MSH2, MSH6, and MLH1. The median age at sarcoma diagnosis was 43 (15-74) years. Soft tissue sarcomas predominated followed by uterine sarcomas and eight histopathological subtypes were represented with recurrent diagnoses of liposarcoma, leiomyosarcoma, and carcinosarcoma. Tumor tissue from eight cases was available for analysis of mismatch-repair (MMR) status using immunohistochemical staining and analysis of microsatellite instability, which revealed MMR defects in six of the eight tumors investigated. This suggests that sarcomas may be part of the HNPCC tumor spectrum and that colorectal cancer should be considered in the family history of sarcoma patients.
Original languageEnglish
Pages (from-to)209-213
JournalFamilial Cancer
Volume8
Issue number3
DOIs
Publication statusPublished - 2009

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000)

Subject classification (UKÄ)

  • Cancer and Oncology

Free keywords

  • Carcinosarcoma
  • Leiomyosarcoma
  • Lynch syndrome
  • Hereditary colorectal cancer
  • MMR
  • MSI
  • Hereditary sarcoma
  • Liposarcoma

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